Class of analgesics and/or anti-inflammatory agents consisting o

Details Class of analgesics and/or anti-inflammatory agents consisting o Class of analgesics and/or anti-inflammatory agents consisting o

1979-09-14

1984-03-27

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424233, A61K 31195, A61K 31615

Patent

active

044394527

ABSTRACT:
A new class of analgesics is provided by substances that inhibit breakdown of endogenous substance such as enkephalins and/or endorphins. The analgesic effect of an enkephalin breakdown inhibitor is greatly enhanced by being combined with an antipyretic, anti-inflammatory analgesic, herein designated as an aspirin-type drug. Specifically, both D-phenylalanine and D-leucine, each an enkephalin breakdown inhibitor, when used separately provides excellent analgesia in animals and man without developing tolerance or addiction in either species. Use of a combination of D-phenylalanine and D-leucine provides a greatly enhanced analgesia approaching the analgesia achieved by morphine. Analgesia by the latter combination is very long-lasting in animals. The injection of a combination of D-phenylalanine and an aspirin-like drug that is antipyretic and anti-inflammatory, in an animal provides a greatly enhanced analgesia approaching the analgesia achieved by morphine. Analgesia by D-phenylalanine is very long-lasting in humans. D-phyenylalanine also exhibits anti-inflammatory character, as demonstrated in animal tests.

REFERENCES:
Merck Index, (1960), 7th Ed. p. 800.
Chem. Abst., 8th Coll. Index (1973), p. 17430s, "Indene-Livei".

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