Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-04-15
2008-04-15
Carlson, Karen Cochrane (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
10558606
ABSTRACT:
The invention relates to the use of an agent that promotes class III SLRP activity in the manufacture of a medicament for the inhibition of blood vessel formation. In addition the invention relates to the use of an agent that promotes class III SLRP activity in the manufacture of a medicament for the prevention and/or treatment of conditions characterised by excessive activity and/or migration of monocytes and/or macrophages. Suitable agents may include class III SLRPs such as opticin. Methods of treatment using agents able to promote class III SLRP activity are also provided.
REFERENCES:
patent: 6413931 (2002-07-01), Yang et al.
patent: 2002/0115589 (2002-08-01), Nixon et al.
patent: 2003/0148351 (2003-08-01), Mayne et al.
patent: 4445630 (1996-06-01), None
patent: WO 97/15330 (1997-05-01), None
patent: WO 98/13071 (1998-04-01), None
patent: WO 98/24466 (1998-06-01), None
patent: WO 01/19386 (2001-03-01), None
Canfield, A.E. et al., “Evidence that tenascin and thrombospondin-1 modulate sprouting of endothelial cells,” J. Cell Sci. (1995) 108:797-809.
Friedman, J.S. et al., “Protein localization in the human eye and genetic screen of opticin,” Human Mol. Genet. (2002) 11(11):1333-1342.
Le Goff et al., “Characterization of opticin and evidence of stable dimerisation in solution,” J. Biol. Chem. (2003) 278:45280-45287.
Pellegrini, B. et al., “Cloning and characterization of opticin cDNA: evaluation as a candidate for canine oculo-skeletal dysplasia,” Gene (2002) 282:121-131.
Slevin, M. et al., “Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses,” J. Biol. Chem. (2002) 277:41046-41059.
Stander, M. et al., “Transforming growth factor-beta and p-21 : multiple molecular targets of decorin-mediated suppression of neoplastic growth,” Cell Tiss. Res. (1999) 296(2):221-227.
Tasheva, E.S., “Analysis of the promoter region of human mimecan gene,” Biochimica et Biophysica Acta (2002) 1575(1-3):123-129.
Tralhao, J.G. et al., “In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer,” The FASEB Journal (Jan. 2003) 17(3):464-466.
Vuillermoz, B. et al., “The small leucine-rich proteoglycan lumican inhibits melanoma progression,” Exp. Cell Res. (2004) 296(2):294-306.
Carlson Karen Cochrane
The University of Manchester
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