Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1995-06-07
2000-02-22
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530300, 530324, 530327, 530326, 514 2, 514 12, 514 13, 514 14, 514 15, 514 16, 4241851, C07K 706, C07K 708, C07K 1400, A61K 3900
Patent
active
060281715
ABSTRACT:
Methods and compositions are provided for regulating surface membrane receptor responses by modulating interaction between MHC Class I antigen and the surface membrane receptor. Various techniques may be employed for enhancing or reducing the interaction between the MHC Class I antigen and surface membrane receptor (e.g., enhancing surface expression of the MHC Class I antigen or employing agents which affect interaction between MHC Class I antigen and surface receptors). The aggregative characteristics of oligopeptides which act as agents in affecting interaction between MHC Class I antigen and surface receptors may be employed in a screening assay for determining drugs which affect interaction between Class I antigen and surface receptors. Active peptide aggregative characteristics may also be employed in a method of administration of effectors of surface receptor response modulation.
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Goldstein Avram
Goodenow Robert S.
Olsson Lennart
Cunningham Thomas M.
Lubet Martha
The Regents of the University of California
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