Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Derived from mollusk
Patent
1995-10-13
1997-12-30
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Derived from mollusk
424520, 424522, 424548, A61K 3556
Patent
active
057027285
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a clam (Lea) extract composition, its preparation method and medical applications, and a pharmaceutical composition containing the extract composition and the preparation method thereof.
BACKGROUND
For a long time, anodyne has been applied to relieve acute pains caused by cancer. The potent anodynes including, for example, dolantin and morphine are commonly used. Because of their side-effects such as leading to addiction etc., people have been trying to develop a new anodyne, which has strong and long-lasting pain-relieving effect but without side-effects such as leading to addiction.
The applicant, after long and careful researches, has developed a potent painkiller which can help patients, especially cancer patients of serious stages, relieve pains without the toxic side-effect, and no addiction has been observed. The applicant has further found that such analgesic can not only treat pains, but also inhibit the growth of tumors.
One objective of the present invention is to provide a clam extract composition, which has the effect of relieving pains on patients, particularly easing pains caused by cancer.
Another objective of the present invention is to provide a method of preparing the clam extract composition.
One further objective of the present invention is to provide a pharmaceutical composition containing the clam extract composition for treating pains.
Another objective of the present invention is to provide a clam extract composition with the effect of inhibiting the growth of tumor.
Other objectives of the present invention may be better understood from the description of the invention.
DISCLOSURE OF THE INVENTION
The clam extract composition of the invention made from clam (Lea) meat is in solid state under normal temperature and pressure and in light yellow, yellow or light brown color, which slightly dissolves in water or low density ethanol but hardly dissolves in organic solvents, such as ether, acetone, chloroform, benzene, acetic ester or n-butanol, etc., and has characteristic absorption between 250 nm to 278 nm shown by the ultraviolet absorption spectrum.
According to the present invention, a method of preparing a clam extract composition comprises the following steps: liquid;
In the preparation, clam meat may be selected from various freshwater clams, and the preferred clam is Anodonta woodiana Lea, Cristaria plicata Lea, Hyriopsis cumingii Lea or a mixture thereof, including mixtures of two or three kinds of clams. Since the sources of clam are different, clam meat is washed with water before grinding to remove dirt or impurities, when necessary. Common grinding equipments, such as meat chopper or grinder, may be used to grind clam meat. In order to grind clam meat into a desired size, colloidal mill may also be used to re-grind the ground meat, or be directly applied to pulverize the clam meat. The smaller size of the ground clam meat is favorable to increase the output rate of extract from clam. Preferably, average size of the ground clam meat is less than 1 mm.
For the step of treatment with acid and alcohol, the used acid is C.sub.2 -C.sub.8 fatty acid with straight chain or branched chain, preferably is C.sub.2 -C.sub.6 fatty acid with straight chain or branched chain, such as acetic acid, citric acid or hydrochloric acid. The mixture of two or more than two kinds of acids may also be applied for the treatment . In the acid mixture, the proportion among the acids is optional. During the treatment with acid and alcohol, pH value shall be controlled at about 2 to 5.5. And the treatment with acid and alcohol is normally conducted under the normal temperature. The mixture is stirred during or after the addition of acid and alcohol, and the stirring may be ended when the mixture becomes homogeneous one. The treatment with acid and alcohol is normally carried out for 1 to 24 hours, preferably 5 to 12 hours. However, the next step can also be immediately begun after the sufficient acid is added.
In the treatment with acid and alcoho
REFERENCES:
patent: 4550020 (1985-10-01), Rothman
Li et al., Cancer Chemotherapy Reports Part 2 vol. 4, No. 3 (Jul. 1974) pp. 97-129.
Li et al., Cancer Research 32: 1201-1205 (Jun. 1972).
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