CL-1957B antibiotic compound and its production

Details CL-1957B antibiotic compound and its production CL-1957B antibiotic compound and its production

1985-08-08

1990-04-17

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549294, A61K 3135

Patent

active

049181009

ABSTRACT:
A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957B which also exhibits antitumor properties.
The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound.
The antibiotic compound CL-1957B, its pharmaceutically acceptable salts, the pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

REFERENCES:
patent: 4550021 (1985-10-01), Umezawa et al.
Umezawa et al., J. Antibiotics, 37(7), 706-711 (1984).
Komiyama et al., J. Antibiotics, 38(2): 220-223 (1985).
Tunac et al., J. Antibiotics, 38(4): 460-465 (1985).
J. Antibiotics, 38(7): 85-101.
J. Antibiotics, 38(7): 85-105.

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