Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-09-26
1988-09-13
Milestone, Norma S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549294, A61K 31365, C07D30938
Patent
active
047710705
ABSTRACT:
A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties.
The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound.
The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.
REFERENCES:
patent: 2434625 (1948-01-01), Ruskin
patent: 3787585 (1974-01-01), Ueno et al.
Tetsuo Hamaoto et al, Jour. of Antibiotics, vol. 36 (1983), pp. 639-645, 646-650.
John M. Venditti, Pharmacological Basis of Cancer Themotherapy, Publ. by The Williams & Wilkins Company (1975), pp. 245-270.
French James C.
Hokanson Gerard C.
Schaumberg John P.
Tunac Josefino B.
Janssen Jerry F.
Milestone Norma S.
Warner-Lambert & Company
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