Citalopram hydrobromide crystal and method for...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S469000

Reexamination Certificate

active

06977306

ABSTRACT:
According to the present invention, citalopram hydrobromide dissolved in a solvent containing at least one member selected from the group consisting of alcohol having 1-3 carbon atoms, water and acetone is crystallized or recrystallized while controlling the cooling rate, thereby to 1) provide an industrial method for crystallizing citalopram hydrobromide, which enables easy control of the crystal characteristics, such as particle size, particle size distribution and aspect ratio and the like of the crystal, and 2) provide citalopram hydrobromide crystal having crystal characteristics useful as a pharmaceutical bulk.

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patent: 2003/0109577 (2003-06-01), Liljegren et al.
patent: 2003/0232881 (2003-12-01), Liljegren et al.
patent: 200 07 303 (2000-07-01), None
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patent: WO 00/23431 (2000-04-01), None
Vilarrasa,Eunibar,Editorial Universitaria de Barcelona, pp. 63-64 (Dec. 1975).
Carré, “Précis de Technologie et de Chimie Industrielle,” vol. 1, pp. 319-320 (Librairie J.-B. Bailliére et Fils, Paris, France, 1938).
U.S. Appl. No. 09/794,755, Petersen et al., filed Feb. 26, 2001, date of publication, Jan. 10, 2002.
“3.1.1 Crystallization by Control of Temperature Change,”Organic Crystals Formation Handbook,pp. 34-35 (2000).

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