Cisapride mini-tablet formulations

Details Cisapride mini-tablet formulations Cisapride mini-tablet formulations

1997-12-22

2000-08-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424489, 424490, 424493, 424494, 424451, 424457, 424458, 424459, A61K 962, A61K 950

Patent

active

061104949

ABSTRACT:
A sustained release cisapride oral dosage formulation suitable for once-daily administration comprises a plurality of mini-tablets containing cisapride or a salt thereof with an organic acid and capable of releasing cisapride at different sites along the gastrointestinal tract. The mini-tablets include a proportion of immediate release tablets and a proportion of tablets which release cisapride in response to the pH environment at a given site in the distal regions of the gastrointestinal tract and which include cisapride or a salt thereof embedded in a matrix of hydrophilic polymer, said matrix being coated with a pH dependent polymer, the formulation having a Cmax/Cmin ratio under steady state conditions of 2:1 or less as evidenced by a substantially flat plasma profile in vivo.

REFERENCES:
patent: 4205073 (1980-05-01), Sherlock et al.
patent: 4259314 (1981-03-01), Lowey et al.
patent: 4369172 (1983-01-01), Schor et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4609909 (1986-09-01), Bechgaard et al.
patent: 4704285 (1987-11-01), Alderman
patent: 4874613 (1989-10-01), Hsiao
patent: 4904479 (1990-02-01), Illum
patent: 4973469 (1990-11-01), Mulligan et al.
patent: 4983401 (1991-01-01), Eichel et al.
patent: 5015479 (1991-05-01), Mulligan et al.
patent: 5026559 (1991-06-01), Eichel et al.
patent: 5102668 (1992-04-01), Eichel et al.
patent: 5128142 (1992-07-01), Mulligan et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5238686 (1993-08-01), Eichel et al.
patent: 5260069 (1993-11-01), Chen
patent: 5326570 (1994-07-01), Rudnic et al.
patent: 5422123 (1995-06-01), Conte et al.
patent: 5447729 (1995-09-01), Belenduik et al.
patent: 5464633 (1995-11-01), Conte et al.
patent: 5472710 (1995-12-01), Klokkers-Bethke et al.
patent: 5495024 (1996-02-01), Itoh et al.
patent: 5500227 (1996-03-01), Oshlack et al.
patent: 5501863 (1996-03-01), Rossling et al.
patent: 5508040 (1996-04-01), Chen
patent: 5558879 (1996-09-01), Chen et al.
patent: 5624683 (1997-04-01), Andoh et al.
patent: B14389393 (1985-10-01), Schor et al.
Drug Development and Industrial Pharmacy, vol. 18, No. 16, 1992, pp. 1719-1739; Hawley, A.R., et al.: "Physical and Chemical Characterization of Thermosoftened Bases for Molten Filled Hard Gelatin Capsule Formulations".

Affiliated with

Also associated with

Rating

Cisapride mini-tablet formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cisapride mini-tablet formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cisapride mini-tablet formulations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1246936