Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane

Details Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane

1978-07-13

1979-10-02

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424287, 548301, C07F 1500

Patent

active

041698460

ABSTRACT:
Cis-platinum (II) complexes of 1,2-diaminocyclohexanes, more particularly, cis-platinum (II) complexes represented by the general formula ##STR1## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans-d- or trans-l-; and R.sup.1 and R.sup.2, which are same, each represent a halogen atom, or R.sup.1 and R.sup.2, when taken together, represent a group represented by the formula ##STR2## wherein R.sup.3 represents a >CH.sub.2 group, a >CHCH.sub.3 or >CHCH.sub.2 CH.sub.3 group are disclosed. Further complexes of uracil and cis-[platinum(II)-cis-, trans-d or trans-l- 1,2-diaminocyclohexane] are disclosed. These complexes have anti-tumor activity in mice. Cis-platinum (II) complex of cis-1,2-diaminocyclohexane is most effective.

REFERENCES:
patent: 3892790 (1975-07-01), Tobe et al.
patent: 3904663 (1975-09-01), Tobe et al.
patent: 4115418 (1978-09-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
Cleare et al., Plat. Met. Rev. 17, 2-13, (1973).
Cleare et al., Chem. Abst. 80, 66593d (1974).
Ridgway et al., Chem. Abst. 84, 130450s (1976).
Gale et al., Chem. Abst. 81, 114588a (1974).
Connors et al., Platinum Coordination Complexes in Cancer Chem., Springer-Verlag N.Y., pp. 51 & 135 (1974).
Belluco, Organometallic & Coordination Chemistry of Platinum, Academic Press, N.Y., pp. 93-95, 547-549 (1974).
Leh et al., J. of Pharmaceutical Sciences, 65(3), pp. 315-328 (1976).
Ward et al., Cancer Treatment Reports, 60(11), pp. 1675-1678 (1976).
Speer et al., Chem. Abst. 84, 54030n (1976).
Connors et al., Chem. Abst. 78, 79753q (1973).
Rosenberg, Plat. Metals Rev. 15, 42-47 (1971).

Affiliated with

Also associated with

Rating

Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cis-platinum (II) complex of trans-l-1,2-diaminocyclohexane will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2369242