Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex havin

Details Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex havin Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex havin

1993-09-07

1995-05-30

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

G07F 1500

Patent

active

054203198

ABSTRACT:
Disclosed is cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex having high optical purity and no toxicity and exhibiting anticancer performance, as shown in the below Formula.
Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex of the invention possesses high optical purity or 99.94% or more e.e. and a melting point of 198.3.degree. to 199.7.degree. C. The complex is synthesized employing as starting material trans-1-1,2-cyclohexamediamine or a derivative of the trans-1-1,2-cyclohexanediamine optically resoluted by means of a high performance liquid chromatography. ##STR1##

REFERENCES:
patent: 4169846 (1979-10-01), Kidani et al.
patent: 4255347 (1981-03-01), Kidani et al.
patent: 4661516 (1987-04-01), Brown et al.
patent: 5068368 (1991-11-01), Nowatari et al.
patent: 5128493 (1992-07-01), Nowatari et al.
Chemical Abstracts, vol. 87, No. 1, issued Jul. 4, 1977, Kidani et al., "Synthesis and anti-tumor activities of platinum (II) complexes of 1,2-diaminocyclohexane isomers and their related isomers," p. 28, column 2, abs. No. 298z, J. Clin. Hematol. Oncol, 1977, 7(1), 197-209.

Affiliated with

Also associated with

Rating

Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex havin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex havin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cis-oxalato(trans-1-1,2-cyclohexanediamine) Pt(II) complex havin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-363498