Cis-N-(2-aminocycloaliphatic)benzamide anti-convulsants

Details Cis-N-(2-aminocycloaliphatic)benzamide anti-convulsants Cis-N-(2-aminocycloaliphatic)benzamide anti-convulsants

1987-07-21

1989-01-31

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548578, A61K 3140, C07D29506

Patent

active

048016047

ABSTRACT:
Certain cis-N-(2-amino-cycloalophatic)benzamides of the formula ##STR1## where m is 0, n is 2, r is alkyl, R.sub.1 and R.sub.2 are taken together with the nitrogen denote a pyrrolidine ring, X and Y are hydrogen or a halogen having an atomic number of from 9 to 35, e.g., cis-3,4-dichloro-N-methyl-n[2-(1-pyrrolidinyl)cyclohexyl]benzamide, and salts thereof, have been found to have CNS seizure blocking or preventing drug action, e.g., anti-convulsant drug properties with little or no analgesic properties.

REFERENCES:
patent: 4098904 (1978-07-01), Szmuszkovics
patent: 4145435 (1979-03-01), Szmuszkovics
patent: 4463013 (1984-07-01), Collins et al.
Tortella, et al.; J. of Pharm. & Exp. Therapeutics, 237 (1986), pp. 49-53.
Tortella, et al., Neuroscience Abstracts, 10 (1984), p. 408.
Clark, et al., J. Med. Chem. 27 (1984), pp. 779-782.
Berman, Neuropharmacology, 23, No. 3, (1984), pp. 367-371.
The Merck Index, 10th Ed. (1983), item 7204.

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