Cis-imidazolines

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S396000, C514S397000

Reexamination Certificate

active

10867154

ABSTRACT:
The present invention provides compounds according to formula Ihaving the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

REFERENCES:
patent: 6734302 (2004-05-01), Kong et al.
patent: 363 061 (1990-04-01), None
patent: 0 433 682 (1991-06-01), None
patent: WO 92/03421 (1992-03-01), None
patent: WO 00/78725 (2000-12-01), None
patent: WO 02/20017 (2002-03-01), None
patent: WO 03/051359 (2003-06-01), None
Seung Hoon Cheon et al, Archives of Pharmacal Research, XP009036613,vol. 20, No. 2, pp. 138-143 (1997).

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