Cis-diammireplatinum(II) organophosphate complexes

Details Cis-diammireplatinum(II) organophosphate complexes Cis-diammireplatinum(II) organophosphate complexes

1979-03-07

1980-11-18

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536117, 424287, C07F 1500

Patent

active

042344999

ABSTRACT:
Cis-diammineplatinum(II) organophosphate complexes where the organophosphate moiety is a glycerophosphate or a monosaccharide phosphate moiety are prepared by reaction of cis-diaquodiammineplatinum(II) salts with alkali metal organophosphates. The resulting complexes possess pronounced anti-tumor activity in mice and low toxicity; consequently, they have high therapeutic indices.

REFERENCES:
patent: 3759896 (1973-09-01), Komatsu et al.
Cleare, "Transition Metal Complexes in Cancer Chemotherapy", Coordination Chemistry Rev. 12 pp. 349-405 (1974).
Cleare et al., Bioinorganic Chemistry 2 pp. 187-210 (1973).
Gale et al., Cancer Treatment Reports 61 pp. 1519-1525 (1977).
Connors et al., Platinum Coordination Complexes in Cancer Chemotherapy, Springer-Verlag, N.Y., pp. 63 to 72 (1973).

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