Cis-diammineplatinum(II) orthophosphate complexes

Details Cis-diammineplatinum(II) orthophosphate complexes Cis-diammineplatinum(II) orthophosphate complexes

1979-03-07

1981-02-03

Sneed, Helen M. S.

Chemistry of inorganic compounds

Phosphorus or compound thereof

Nitrogen containing

424128, C01B 2106, C01B 2500

Patent

active

042488400

ABSTRACT:
Cis-diammineplatinum(II) orthophosphate complexes are prepared by reaction of diaquo-cis-diammineplatinum(II) salts with alkali metal orthophosphates. The resulting complexes possess pronounced anti-tumor activity in mice and low toxicity; consequently, they have high therapeutic indices.

REFERENCES:
Mellor, A Comprehensive Treatise on Inorganic & Theoretical Chem, Longmans' Green & Co., N.Y., pp. 416-417, (1937).
Cleare et al., Bioinorganic Chemistry, 2, pp. 187-210, (1973).
Gale et al., Cancer Treatment Reports, 61, pp. 1519-1525, (1977).
Rosenberg, Nature, 222, pp. 385-386, (1969).
Belluco, Organometallic and Coordination Chemistry of Platinum Academic Press, N.Y., pp. 93-95, (1974).

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