Cis-bicyclo[3.3.0]octane derivatives, medicaments containing the

Details Cis-bicyclo[3.3.0]octane derivatives, medicaments containing the Cis-bicyclo[3.3.0]octane derivatives, medicaments containing the

1982-11-17

1985-04-09

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 56, 549333, 549336, 568327, 562466, 514569, C07C 6976, C07C 6524

Patent

active

045103232

ABSTRACT:
Cis-bicyclo[3.3.0]octane derivatives corresponding to the formula ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group or a cation and wherein R.sub.2 represents a cyclohexyl or an adamantyl group. In these compounds the phenyl radical may be arranged with respect to the double bond in the EZ- or in the E-configuration and at the carbon atom bearing the group R.sub.2 the molecule may have the RS- or S-configuration. The compounds are prepared by reacting compounds of the formulae ##STR2## wherein R.sub.1 and R.sub.2 have the same meaning as above and R.sub.6 represents hydrogen or a protecting group. Medicaments containing these compounds act as inhibitors of blood platelet aggregation and (in higher doses) as blood pressure lowering agents.

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