Cis-acting sequences for intracellular localization of RNA

Details Cis-acting sequences for intracellular localization of RNA Cis-acting sequences for intracellular localization of RNA

1994-10-07

1997-06-24

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435375, 514 44, 536 231, 536 245, 935 33, C12N 500, G07H 2104

Patent

active

056416750

ABSTRACT:
Disclosed are the particular 3' noncoding nucleotide sequences (zipcode and zipcode elements) that cause .beta.-actin mRNA (and .beta.-actin protein synthesis) to be localized in specific regions of the cytoplasm. Also disclosed is the discovery that zipcode function can be fully inhibited by antisense oligonucleotides.

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