Cis-4-(2,2,3,3-tetrafluoropropoxy)-cinnamonitrile and trans-4-(2

Details Cis-4-(2,2,3,3-tetrafluoropropoxy)-cinnamonitrile and trans-4-(2 Cis-4-(2,2,3,3-tetrafluoropropoxy)-cinnamonitrile and trans-4-(2

1995-11-06

1997-09-02

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25507

Patent

active

056634102

ABSTRACT:
The present invention relates to the compounds cis-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and to a process for their preparation. The process relates to the preparation of cis-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile or optionally one of these two compounds, by fractionally distilling a mixture containing cis- and trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile under reduced pressure, separating off a main fraction containing at least 80% by weight of cis-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile and a main fraction containing at least 80% by weight of trans-4-(2,2,3,3-tetrafluoropropoxy)cinnamonitrile, further purifying these main fractions by means of fractional crystallization or melt crystallization or adjusting one of these main fractions by isomerization to the cis/trans isomer ratio corresponding to the particular thermodynamic equilibrium and returning it to the process and returning the remaining fractions to the process directly or after isomerization.

REFERENCES:
Boyle, F. T., et al, Am. NY Acad. Sci. 544:86-100 (1988) (Antifungal Drugs) .

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