cis-3,4-chroman derivatives useful in the prevention or treatmen

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514212, 5142305, 514320, 514375, 514456, 540596, 544105, 546196, 548235, 548525, 549389, 549406, A61K 3140, C07D40510

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active

060432691

ABSTRACT:
The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estrogen related diseases or syndromes.

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Salman et al., J. Med. Chem., 26, pp. 592-595, (1983).
Bundgaard "Design of prodrugs" Elsevier, p. 3-9, 1985.
Durani et al. "a possible basis for structure-fuction relationship of estrogens" CA 95:109086, 1981.

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