Cis-2-benzoyl-3-hydroxy-2-alkenonitriles as anti-inflammatory ag

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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548247, 260429R, 260465E, 260465F, 260465G, 260465R, 2604656, 260544D, 2605705C, 546230, A61K 31275, C07C12176

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041736508

ABSTRACT:
This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being certain substituted cis-2-benozyl-3-hydroxy-2-alkenonitriles and/or the pharmacologically acceptable cationic salts thereof.

REFERENCES:
patent: 3658838 (1972-04-01), Kiehne et al.
patent: 4061767 (1977-12-01), Ertel et al.
Panizzi, Chemical Abstracts, vol. 42, 559-561 (1948).
Vila et al., Chemical Abstracts, vol. 47, 9940 (1952).
Edwards et al., Chemical Abstracts, vol. 50, 1505 (1956).

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