Cis-2,6-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutanol co

Details Cis-2,6-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutanol co Cis-2,6-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutanol co

1976-04-15

1977-06-21

Jaisle, Cecilia M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424267, C07D21132

Patent

active

040311015

ABSTRACT:
cis-2,6-Dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutanol; and acid-addition salts. The compounds are pharmacological agents, especially antiarrythmic agents. The compounds can be produced by reacting phenyl lithium or phenylmagnesium halide with cis-.gamma.-(2,6-dimethylpiperidino)butyrophenone or a lower alkyl ester of cis-2,6-dimethyl-1-piperidinebutyric acid; by reacting .alpha.-(3-halopropyl)-.alpha.-phenylbenzyl alcohol with cis-2,6-dimethylpiperidine, or by reacting cis-1- (3-lithiopropyl)-2,6-dimethylpiperidine with benzophenone.

REFERENCES:
patent: 2649444 (1953-08-01), Barrett
patent: 2989533 (1961-06-01), Stein et al.
patent: 3088869 (1963-05-01), Zirkle
patent: 3375278 (1968-03-01), Moffett
patent: 3423511 (1969-01-01), Carlson et al.
patent: 3517016 (1970-06-01), Pedrazzoli et al.
CA.48:2112-2113 (1954), citation abstract of Brit. Pat. No. 683,950, (12-10-52).

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