Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
424278, C07D30346, C07D30300
Amides and thioates of (-)(cis-1,2-epoxypropyl)-phosphonic acid and phosphonothioic acid are prepared by converting (-)(cis-1,2-epoxypropyl)phosphonic acid or phosphonothioic acid or a salt thereof to an acid halide and reacting the acid halide with an amine, and by reacting the phosphonic acid or a salt thereof with an amine in the presence of a carbodiimide. The novel (-)(cis-1,2-epoxypropyl)phosphonic and phosphonothioic amides are active antibacterial agents.
patent: 3463813 (1969-08-01), Dickerson
patent: 3485897 (1969-12-01), Jenker
patent: 3496080 (1970-02-01), Harris
patent: 3520907 (1970-07-01), Taylor et al.
patent: 3522303 (1970-07-01), Ulrich
Christensen Burton G.
Fordice Michael W.
Johnston David B. R.
Behan J. Jerome
Gallagher Richard J.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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