Circulation-active tetrahydropyridine-3-carbonitrile derivatives

Details Circulation-active tetrahydropyridine-3-carbonitrile derivatives Circulation-active tetrahydropyridine-3-carbonitrile derivatives

1988-01-04

1989-12-05

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514344, 546263, 546284, 546286, C07D21355, C07D21357, A61K 3144

Patent

active

048853038

ABSTRACT:
Circulation active tetrahydropyridines of the formula ##STR1## in which R.sup.1 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 20 carbon atoms and can be interrupted in the chain by an oxygen atom or a sulphur atom and/or can be substituted by halogen, cyano, hydroxyl, acyloxy, nitro or nitrooxy, or by a phenyl, phenoxy, phenylthio or phenylsulphonyl group which is optionally substituted by halogen, cyano, dialkylamino with in each case 1 or 2 carbon atoms per alkyl group, alkoxy with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms, trifluoromethyl or nitro, or by an .alpha.-, .beta.- or .gamma.-pyridyl group, or by an amino group, this amino group carrying 2 identical or different substituents from the group comprising alkyl with up to 4 carbon atoms, alkoxyalkyl with up to 4 carbon atoms, phenyl and aralkyl, and these substitutents optionally forming, with the nitrogen atom, a 5- to 7-membered ring which can contain, as a further hetero atom, an oxygen or sulphur atom or an N-phenyl or N-alkyl grouping, this alkyl group containing 1 to 3 carbon atoms,

REFERENCES:
Chemical Abstract, vol. 79, No. 15, Oct. 15, 1973, Columbus, Ohio, M. F. Chasle-Pommert et al., "Reactions of Travalent Phosphorus Compounds with Positive Halogen Compound", p. 418.

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