Circular dichroism detector for HPLC

Optics: measuring and testing – By polarized light examination

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356368, G01J 400

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061185361

ABSTRACT:
A circular dichroism detector includes a light source having a large emission intensity in the ultraviolet region such as an HgXe lamp or Hg lamp, a diffraction grating for wavelength dispersing the light emitted from the light source, a polarizer for linearly polarizing the light emitted from the light source, a PEM for modulating wavelength dispersed linearly polarized light to alternately produce left-handed circularly polarized light and right-handed circularly polarized light, a flow cell through which the circularly polarized light will be passed, and a photodiode for detecting the circularly polarized light passing through the flow cell.

REFERENCES:
patent: 4498774 (1985-02-01), Yeung et al.
patent: 5153679 (1992-10-01), Gilby
patent: 5191260 (1993-03-01), Kawai et al.
Purdie, N. et al.: "Circular Dichroism--I. Theory and Practice," TrAC, Trends in Analytical Chemistry, vol. 9, No. 3, Mar. 1, 1990, pp. 94-97.
Purdie, N. et al.: "Circular Dichroism--II. Analytical Applications," TrAC, Trends in Analytical Chemistry, vol. 9, No. 4, Apr. 1, 1990, pp. 136-142.
Mannschreck, A., "On-Line Measurement of Circular Dichroism Specta During Enantioselective Liquid Chromatography," TrAC., Trends in Analytical Chemistry, vol. 12, No. 5, May 1, 1993, pp. 220-225.

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