Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-03-10
1995-02-21
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514216, 514248, 540478, 540585, 544235, 534558, 564251, A61K 3155, A61K 3150, C07D23728, C07D40112
Patent
active
053915496
ABSTRACT:
A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT.sub.3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical formulations containing the same for the prevention and/or treatment of various disorders such as nausea and/or emesis caused by anticancer drugs or X-ray treatment, central nervous disorders such as anxiety and/or neuropathy, gastroenteric diseases such as indigestion, chronic gastritis, digestive ulcer, irritable bowel syndromes and the like, hemicrania, cluster headache, trigeminal neuralgia, arrhythmia and the like.
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Evans et al., "Molecular Modeling of 5-HT.sub.3 Receptor Ligands", Pharmacology Biochemistry and Behavior, vol. 40, pp. 1033-1040, U.S.A. (1991).
Maruyama Akira
Ogawa Shigeru
Tobe Akihiro
Yamazaki Satoshi
Bernhardt Emily
Mitsubishi Kasei Corporation
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