Cinnamide compound

Details Cinnamide compound Cinnamide compound

2005-05-25

2010-02-23

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S326000

Reexamination Certificate

active

07667041

ABSTRACT:
The present invention relates to a compound represented by Formula (I):(wherein Ar1represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1and R2represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted)or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by Aβ. According to the present invention, a therapeutic or preventive agents for diseases caused by Aβ can be provided.

REFERENCES:
patent: 4910200 (1990-03-01), Curtze et al.
patent: 5281626 (1994-01-01), Oinuma et al.
patent: 5563162 (1996-10-01), Oku et al.
patent: 5985856 (1999-11-01), Stella et al.
patent: 6235728 (2001-05-01), Golik et al.
patent: 6306870 (2001-10-01), Bombrun
patent: 7053087 (2006-05-01), Beatch et al.
patent: 7138414 (2006-11-01), Schoenafinger et al.
patent: 7300936 (2007-11-01), Parker et al.
patent: 2001/0051642 (2001-12-01), Ahn et al.
patent: 2002/0128263 (2002-09-01), Mutel et al.
patent: 2003/0195201 (2003-10-01), Bo et al.
patent: 2003/0208082 (2003-11-01), Mutel et al.
patent: 2003/0225070 (2003-12-01), Mutel et al.
patent: 2004/0034096 (2004-02-01), Jolidon et al.
patent: 2004/0038969 (2004-02-01), Doherty et al.
patent: 2004/0063770 (2004-04-01), Ahn
patent: 2004/0087798 (2004-05-01), Yamada
patent: 2004/0127494 (2004-07-01), Parker et al.
patent: 2004/0127555 (2004-07-01), Snow et al.
patent: 2004/0152743 (2004-08-01), Schoenafinger et al.
patent: 2004/0192743 (2004-09-01), Mjalli et al.
patent: 2004/0235864 (2004-11-01), Graczyk et al.
patent: 2005/0070538 (2005-03-01), Cheng et al.
patent: 2005/0131043 (2005-06-01), Mutel et al.
patent: 2005/0187277 (2005-08-01), Mjalli et al.
patent: 2006/0004013 (2006-01-01), Kimura et al.
patent: 2007/0117798 (2007-05-01), Kimura et al.
patent: 2007/0117839 (2007-05-01), Kimura et al.
patent: 2007/0219181 (2007-09-01), Kimura et al.
patent: 2008/0070902 (2008-03-01), Kimura et al.
patent: 2008/0085894 (2008-04-01), Parker et al.
patent: 2008/0096892 (2008-04-01), Cheng et al.
patent: 2008/0280948 (2008-11-01), Baumann et al.
patent: 2009/0048213 (2009-02-01), Kimura et al.
patent: 3541716 (1987-05-01), None
patent: 0219756 (1987-04-01), None
patent: 0 973 768 (2003-07-01), None
patent: 1 757 591 (2007-02-01), None
patent: 1 808 432 (2007-07-01), None
patent: 1 953 151 (2008-08-01), None
patent: 1 953 158 (2008-08-01), None
patent: P 2006 3920 (2006-05-01), None
patent: 3-206042 (1991-09-01), None
patent: 7-2780 (1995-01-01), None
patent: 8283219 (1996-10-01), None
patent: 10-510512 (1998-10-01), None
patent: 11-228548 (1999-08-01), None
patent: 3176365 (2001-04-01), None
patent: 2001-508767 (2001-07-01), None
patent: 2001-527083 (2001-12-01), None
patent: 2003-206280 (2003-07-01), None
patent: 2004-531519 (2004-10-01), None
patent: 2005-518371 (2005-06-01), None
patent: 2005-526807 (2005-09-01), None
patent: 2005-531596 (2005-10-01), None
patent: 2005-533092 (2005-11-01), None
patent: 2006-502247 (2006-01-01), None
patent: 2007-504282 (2007-03-01), None
patent: WO91/12237 (1991-08-01), None
patent: WO-96/10559 (1996-04-01), None
patent: WO97/43287 (1997-11-01), None
patent: WO-98/24785 (1998-06-01), None
patent: WO-00/07993 (2000-02-01), None
patent: WO-00/50391 (2000-08-01), None
patent: WO-00/51981 (2000-09-01), None
patent: WO-01/68585 (2001-09-01), None
patent: WO01/81312 (2001-11-01), None
patent: WO-03/053912 (2003-07-01), None
patent: WO-03/082292 (2003-10-01), None
patent: WO-03/101927 (2003-12-01), None
patent: WO-2004/007455 (2004-01-01), None
patent: WO-2005/020921 (2005-03-01), None
patent: WO-2005/115990 (2005-12-01), None
patent: WO-2006/046575 (2006-05-01), None
patent: WO-2006/112550 (2006-10-01), None
patent: WO-2007/034282 (2007-03-01), None
patent: WO-2007/060810 (2007-05-01), None
patent: WO-2008/013213 (2008-01-01), None
patent: WO-2008-097538 (2008-08-01), None
patent: WO-2008/137139 (2008-11-01), None
patent: WO-2008/156580 (2008-12-01), None
patent: WO-2009/020580 (2009-02-01), None
Foreign Search Report: Application #2006146070/04(050338) dated 2008.
W. J. Ross et al., Journal of Medicinal Chemistry, 1973, vol. 16, No. 4, pp. 347-352.
D. C. Guiroy et al., Acta Neuropathol (1991) 82: 87-92.
Office Action dated Jul. 11, 2008, that issued in connection with copending U.S. Appl. No. 11/594,150.
Masahiko Kato et al., Chem. Pharm. Bull., 42 (12), 2546-2555 (1994).
Yuesong Gong et al.; Proceeding National Academy of Science, vol. 100, No. 18, pp. 10417-10422, Sep. 2, 2003.
Christoph Hock et al.; Neuron, vol. 38, No. 4, pp. 547-554, May 22, 2003.
Joseph T. Jarrett et al.; Biochemistry; vol. 32, No. 18, pp. 4693-4697, May 11, 1993.
George G. Glenner et al.; Biochemical and Biophysical Research Communications; vol. 120, No. 3, pp. 885-890, May 16, 1984.
Colin L. Masters et al.; Proceeding National Academy of Science; vol. 82, No. 12, pp. 4245-4249, Jun. 1985.
Gunnar K. Gouras et al.; American Journal of Pathology, vol. 156, No. 1, pp. 15-20, Jan. 2000.
D. Scheuner et al.; Nature Medicine, vol. 2, No. 8, pp. 864-870, Aug. 1996.
Mark S. Forman et al.; The Journal of Biological Chemistry; vol. 272, No. 51, pp. 32247-32253, Dec. 19, 1997.
Mark S. Shearman et al.; Biochemistry; vol. 39, No. 30, pp. 8698-8704, 2000.
Huw D. Lewis et al.; Biochemistry, vol. 42, No. 24, pp. 7580-7586, 2003.
Thomas A. Lanz et al., The Journal of Pharmacology and Experimental Therapeutics; vol. 39, No. 1, pp. 49-55, 2004.
Gwendolyn T. Wong et al.; The Journal of Biological Chemistry, vol. 279, No. 13, pp. 12876-12882, Mar. 26, 2004.
John P. Blass; Journal of Neuroscience Research, vol. 66, No. 1, pp. 851-856, 2001.
Genevieve Evin et al.; NeuroReport; vol. 13, No. 5, pp. 719-723, Apr. 16, 2002.
Osamu Yasuhara et al.; Neuroscience Letters, vol. 171, Nos. 1 and 2, pp. 63-66, 1994.
Jan T. Keller et al.; Nature Medicine, vol. 2, No. 1, pp. 93-95, Jan. 1996.
Takahiko Tokuda et al.; Annals Neurology, vol. 41, No. 2, pp. 271-273, Feb. 1997.
Yorihide Hayashi et al.; Brain Research; vol. 789, No. 2, pp. 307-314, 1998.
Helene Barelli et al.; Molecular Medicine, vol. 3, No. 10, pp. 695-707, Oct. 1997.
Michael E. Calhoun et al.; Proceeding National Academy of Science, vol. 96, No. 24, pp. 14088-14093, Nov. 23, 1999.
B. Dermaut et al.; Brain, vol. 124, No. 12, pp. 2383-2392, 2001.
P. Cras et al.; Acta Neuropathol, vol. 96, No. 3, pp. 253-260, 1998.
Martin C. Herzig et al.; Nature Neuroscience, vol. 7, No. 9, pp. 954-960, Sep. 2004.
Sjoerd G. Van Duinen et al.; Proceeding National Academy of Science, vol. 84, No. 16, pp. 5991-5994, Aug. 1987.
Efrat Levy et al.; Science, vol. 248, No. 4959, pp. 1124-1126, 1990.
Simon M. Laws et al.; Neurobiology of Aging, vol. 23, No. 1, pp. 55-58, 2002.
E. Vaucher et al.; Experimental Neurology, vol. 175, No. 2, pp. 398-406, 2002.
Dave Morgan et al.; Nature, vol. 408, No. 6815, pp. 982-985, Dec. 2000.
Paula M. Moran et al.; Proceeding National Academy of Science, vol. 92, No. 12, pp. 5341-5345, 2002.
Milla Koistinaho et al.; Proceeding National Academy of Science, vol. 99, No. 3, pp. 1610-1615, Feb. 5, 2002.
Fangyi Zhang et al.; The Journal of Neuroscience, vol. 17, No. 20, pp. 7655-7661, Oct. 15, 1997.
Marcin Sadowski et al.; Neurochemical Research, vol. 29, No. 6, pp. 1257-1266, Jun. 2004.
S. O'Riordan et al.; Neurology, vol. 59, No. 7, pp. 1108-1110, Oct. 2002.
Jochen Gehrmann et al.; Glia; vol. 15, No. 2, pp. 141-151, 1995.
Wanda F. Reynolds et al.; Experimental Neurology, vol. 155, No. 1, pp. 31-41, 1999.
Douglas H. Smith et al.; NeuroMolecular Medicine, vol. 4, No. 1 and 2, pp. 59-72, 2003.
Miho Matsubara-Tsutsui et al.; American Journal of Medical Genetics, vol. 114, No. 3, pp. 292-298, 2002.
Marina D. Kirkitadze et al.; Journal of Neuroscience Research, vol. 69, No. 5, pp. 567-577, 2002.
Bernd O. Evert et

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