Cinnamic acid derivatives, their preparation, and pharmaceutical

Details Cinnamic acid derivatives, their preparation, and pharmaceutical Cinnamic acid derivatives, their preparation, and pharmaceutical

1980-09-03

1982-01-05

Breitenstein, G. T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26050111, 26050112, 560 21, 560 42, 560 34, 560 12, 560 13, 562451, 562430, 562435, 562439, 564 49, 564 51, 564 99, 564162, 564165, 424309, 424316, 424321, 424322, 424324, A61K 31195, C07C10130, C07C10326, A61K 31165

Patent

active

043094430

ABSTRACT:
A compound of the formula (I): ##STR1## or a pharmaceutically acceptable ester, amide or salt thereof wherein R.sub.1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl group; R.sub.3 is a hydrogen, chlorine or bromine atom or a hydroxyl group; R.sub.4 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R.sub.5 is a hydrogen atom or a methyl group; R.sub.6 is a hydrogen atom or a methyl group; R.sub.7 is a hydrogen atom or a methyl or ethyl group; R.sub.8 is a hydrogen atom or a methyl or ethyl group; X is an oxygen atom or a bond, and Y is an alkylene group of up to 5 carbon atoms, or a bond has been found to possess anti-obesity and/or anti-hyperglycaemic activity.

REFERENCES:
patent: 3818101 (1974-06-01), Baile et al.
patent: 3828095 (1974-08-01), Boschetti et al.
patent: 3836666 (1974-09-01), Koppe et al.
patent: 3857873 (1974-12-01), Schwender et al.
patent: 3872147 (1975-03-01), Koppe et al.
patent: 4146638 (1979-03-01), Renth et al.
patent: 4165384 (1979-08-01), Carlsson et al.
patent: 4191765 (1980-03-01), Fritsch et al.
Hartley et al., J. Med. Chem., vol. 13, No. 4 (1970), pp. 674-680.

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