Cinnamaldehyde derivatives inhibiting growth of tumor cell...

Details Cinnamaldehyde derivatives inhibiting growth of tumor cell... Cinnamaldehyde derivatives inhibiting growth of tumor cell...

2005-09-27

2005-09-27

Richter, Johann (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S441000, C514S699000, C514S705000

Reexamination Certificate

active

06949682

ABSTRACT:
The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.

REFERENCES:
Bergens et al. Homogeneous Catalysis: Catalytic Intamolecular Conversion of 1,4-Dialdehydes to gamma-Lactones. Organometallics, 1990, 9, p 566-571.
Gendy et al. Synthesis of 1,4-Diaryl-2,3-diformylbutadienes. Synthesis, 1980, 11, p898-899.
Peter L. Toogood, Progress Toward the Development of Agents to Modulate the Cell Cycle, Current Opinion in Chemical Biology 2002, 6:472-478 (2002 Elsevier Science Ltd.).
Marcos Malumbres, et al., To Cycle or not to Cycle: A Critical Decision in Cancer, Nature, vol. 1 Dec. 2001, Reviews 222-231 (2001 Nature Publishing Group).

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