Chymotrypsin model

Details Chymotrypsin model Chymotrypsin model

1986-06-19

1988-10-11

Wiseman, Thomas G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435196, 435213, 502 7, 502107, 536103, C08B 3018, C08B 3716, C12N 916, C12N 976, B01J 3736, B01J 3100

Patent

active

047772506

ABSTRACT:
Low molecular weight chymotrypsin analogs exhibiting the binding and catalytic groups of the real enzyme of the formula ##STR1## where D equals .alpha.-, .beta.- or .gamma.-cyclodextrin; P is X or (CH.sub.2).sub.n X, wherein n equals 0 to 2 and X equals S, NH, or 0; Q equals substituted phenyl with the carboxylate ion attached to the ortho position or equals (CH.sub.2).sub.n, wherein n equals 0 to 3; and R equals hydrogen --CH.sub.3 or --C.sub.2 H.sub.5.
The enzyme models are useful as an analytical model mimicking the real enzyme, a stain remover, a laundry detergent additive, a food additive, and as a therapeutic agent for treating enzyme deficiencies.

REFERENCES:
D'Souza, V. T., Hanabusa, K., O'Leary, T., Gadwood, R. C. and Bender, M. L. (1985) Biochem Biophys Res Commun 129,727.
Breslow, et al., Bioorg, Chem., 12, 206-220 (1984).
Van Etten, R. L. et al., J. Am. Chem. Soc., 89, 3253-3262 (1967).
Mallick, et al., J. Am. Chem. Soc., 106, 7252-7254 (1984).
Breslow, et al., J. Am. Chem. Soc. 100, 3227-3229 (1978).
Breslow, et al., J. Am. Chem. Soc. 105, 1390-1391 (1983).
Angew, Chem. 78, 641 (1966).
Schonbaum, G. R. et al., J. Biol. Chem., 236, 2930-2935 (1961).

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