Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1981-05-13
1984-03-27
Rosen, Sam
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3748
Patent
active
044394233
ABSTRACT:
An improved method for treating an intervertebral spinal disc in a mammalian subject which disc exhibits an abnormal condition, characterized by a reduced risk of toxic effect to the subject is provided which comprises, injecting in said disc an amount of a pharmaceutically acceptable solution of a purified chymopapain essentially free of proteolytically inactive and/or toxic protein components, said purified chymopapain being used in an amount sufficient to selectively dissolve the nucleus pulposus of said disc.
Pharmaceutical compositions are also provided for said method which include a purified proteolytically active lyophilized chymopapain, essentially free of proteolytically inactive and toxic components, and an activating amount of a pharmaceutically acceptable reducing agent.
REFERENCES:
patent: 2313875 (1980-12-01), Jansen et al.
patent: 3248300 (1966-04-01), Burdick
patent: 3274072 (1966-09-01), Burdick
patent: 3281331 (1966-10-01), Bergkvist
patent: 3284316 (1966-11-01), Cayle
patent: 3320131 (1967-05-01), Smith
patent: 3558433 (1971-01-01), Stern
patent: 4039682 (1977-08-01), Ausman et al.
Ebata et al.,--The J. of Biological Chemistry, vol. 237, No. 4, Apr. 1962, pp. 1086-1094.
Skelton--Chem. Abst., vol. 70, (1969), p. 34597k.
Summers et al., Genetics, vol. 60, Aug. 1971, pp. 603-607.
GRAS Substances--Sulfiting Agents 47 F.R. 29956, Jul. 1982.
Sussmuth et al., Mutagen Res., vol. 40, 229-236, (1976).
Erlanger, Arch. Biochem. Biophys. 95, 271-278, (1961).
Baines et al., J. Biochem 177, 541-548, (1979).
Jansen and Balls, J. Bio. Chem., vol. 137 459, (1941).
The Merck Index, Ninth Edition, Entry No. 2261, p. 293.
Cayle and Lopez--Ramos, Abstracts of Papers of the 140th Meeting of the Am. Chem. Soc'y., Chicago, p. 19C, (1961).
F. Mukai et al., Biochim. Biophys. Res. Comm. 39, 983-988, (1970).
Shapiro, Mutagen Res., vol. 39, 149-176, (1977).
McCluskey and Thomas, The Removal of Cartilage Matrix, In Vivo, by Papain, 108 J. Exp. Med. 371, (1958).
Potter et al., The Removal of Cartilage Matrix by Papain, 112 J. Exp. Med. 1173, (1960).
Hirsch, Studies on the Patholoy of Low Back Pain, 41B J. Bone Jt. Surg., 237, (1959).
Mitchell et al., The Chemical Background of Intervertebral Disc Prolapse, 43B J. Bone Jt. Surg., 141, (1961).
Harris and McNab, Structural Changes in the Lumbar Intervertebral Discs, 36B J. Bone Jt. Surg., 304, (1954).
Feffer, Treatment of Low-Back and Sciatic Pain by the Injection of Hydrocortisone into Degenerated Intervertebral Discs, 38A J. Bone Jt. Surg., 585, (1956).
Davidson et al., Biochemical Alterations in Herniated Disks, 234 J. Bio. Chem. 2951, (1959).
Smith et al., Enzyme Dissolution of the Nucleus Pulposus in Humans, Nature, vol. 198, 1311, (1963).
Kunimitsu and Yasunobu, Biochim. Biophys. Acta, vol. 139, pp. 405-417, (1967).
Rosen Sam
Smith Laboratories, Inc.
LandOfFree
Chymopapain and method for its use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chymopapain and method for its use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chymopapain and method for its use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1755594