Chronic treatment regimen using glucagon-like insulinotropic...

Details Chronic treatment regimen using glucagon-like insulinotropic... Chronic treatment regimen using glucagon-like insulinotropic...

2011-08-02

2011-08-02

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Glucagon; related peptides

C530S324000, C530S399000, C514S006800, C514S007200, C514S021300

Reexamination Certificate

active

07989585

ABSTRACT:
The present invention encompasses a method of treating a disease by maintaining chronic steady state serum levels of a GLP-1 compound within a specified range.

REFERENCES:
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patent: WO 02 48183 (2002-06-01), None
Deacon, C. F., et al. “Depeptidyl Peptidase IV Resistant Analogues of Glucagon-like Peptide-1 Which Have Extended Metabolic Stability and Improved Biological Activity,” Diabetologia, Berlin, DE, vol. 41, 1998, pp. 271-278. XP002202152.
Greig, N. H., et al. “Once Daily Injection of Exendin-4 to Diabetic Mice Achieves Long-Term Beneficial Effects on Blood Glucose Concentrations,” Diabetologia, Berlin, DE, vol. 42, No. 1, Jan. 1999, pates 45-50, XP 000971927.
Knudsen, L. B., et al, “Potent Derivatives of Glucagon-Like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration,” Journal of Medicinal Chemistry, American Chemical Society. Washington, US, vol. 43, No. 9,(May 4, 2000), pp. 1664-1669,XP 002222050.

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