Chronic, bolus administration of D-threo methylphenidate

Details Chronic, bolus administration of D-threo methylphenidate Chronic, bolus administration of D-threo methylphenidate

1997-09-29

1999-07-13

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

059227362

ABSTRACT:
Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.

REFERENCES:
patent: 2507631 (1950-05-01), Hartmann et al.
patent: 2957880 (1960-10-01), Rometsch
patent: 4992445 (1991-02-01), Lawter et al.
patent: 5104899 (1992-04-01), Young et al.
patent: 5114946 (1992-05-01), Lawter et al.
patent: 5217718 (1993-06-01), Colley et al.
patent: 5283193 (1994-02-01), Yamamoto et al.
patent: 5284769 (1994-02-01), Evans et al.
patent: 5331000 (1994-07-01), Young et al.
patent: 5362755 (1994-11-01), Barberich et al.
patent: 5375693 (1994-12-01), Woosley et al.
patent: 5449743 (1995-09-01), Kobayashi et al.
patent: 5733478 (1998-03-01), Creech et al.
patent: 5733756 (1998-03-01), Zeitlin et al.
patent: 5837284 (1998-11-01), Mehta et al.
Angrist et al., J. Clin. Psychopharm., 1992, 12(4), 268-272.
Barkley et al., Pediatrics, 1990, 86(2), 184-192.
Barkley et al., Pediatrics, 1991, 87(4), 519-531.
Golinko, Prog. Neuro-Psychopharmacol. Biol. Psychiat., 1984, 8, 1-8.
Greenhill, "Pharmacologic Treatment of Attention Deficit Hyperactivity Disorder", Pediatric Psychopharmacology, 1992, 15(1), 1-27.
Holmes et al., J. Clin. Psychiatry, 1989, 50(1), 5-8, Biosis Abstract No. 87129969.
Scott, "Stereoisomers and Drug Toxicity", Drug Safety, 1993, 8(2), 149-159.
Srinivas et al., Clin. Pharmacol. Ther., 1992, 52(5), 561-568, Biosis Abstract No. 95066168.
White et al., J. Clin. Psychiatry, 1992, 53(5), 153-156.
Aoyama et al., "Pharmacolinetics and pharmacodynamics of (+)-threo-methylphenidate enantiomer in patients with hypersomnia", Clin. Pharmacol. Ther., 1994, 55(3), 270-276.
Bowden et al., "Reactions of Carbonyl Compounds in Basic Solutions the Alkaline Hydrolysis of N-Methyl, N-Phenyl, and Bicyclo Lactams Penicillins, and N-Alkyl-N-methylacetamides", J. Chem. Soc. Perkin Trans., 1990, 12, 2111-2116.
Brown G., "The Use of Methylphenidate for Cognitive Decline Associated with HIV Disease", Int'l J. Psychiatry Med., 1995, 25(1), 21-37.
Brown, "Pharmacological Action and Drug Development", Chirality in Drug Design and Synthesis, Academic Press Inc., 1990, 4-7.
Corey et al., "A New Synthetic Approach to the Penicillins", J. Am. Chem. Soc., 1965, 87(11), 2518-2519.
Ding et al., Cis-and trans-Axetidin-2-ones from Nitrones and Copper Acetylide, J. Chem. Soc. Perkin, 1976, 22, 2382-2386.
Douzenis et al., "Phychiatric Disorder in HIV Disease: Description of 200 Referrals to a Liaison psychiatry Service", Proc 7th. Int'l Conf. AIDS, 1991, 215 (M.B.2135--Summary).
Earle et al., Synthesis and Hydrolysis of some Fused-ring .beta.-Lactams, J. Chem. Soc., 1969, 2093-2098.
Greenhill L., "Attention-Deficit Hyperactivity Disorder", Child & Adol. Psych. Clin. N.A., 1995, 4(1), 123-168.
Hou, J.P. et al., "Beta-Lactam Antibiotics: Their Physiochemical Properties and Biological Activities in Relation to Structure", J. Pharm. Sci., 1971, 60(4), 503-532.
Klibanov, "Asymmetric Transformations Catalyzed by Enzymes in Organic Solvents", Acc. Chem. Res., 1990, 23, 114-120. B., 1966, 21, 297.
Navia et al., "The AIDS Dementia Complex: I. Clinical Features", Annals of Neurology, 1986, 19, 517-524.
Patrick et al., "Pharmacology of the Enantiomers of threo-Methylphenidate", J. Pharmacol & Exp. Terhap., 1987, 241, 152-158.
Rieder et al., "Diagnosis of Sulfonamide Hypersensitivity Reactions by In-Vitro "Rechallenge" with Hydroxylamine Metabolites", Ann. Intern Med., 1989, 100, 286-289.
Srinivas et al., "Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans", Pharmacol Res., 1993, 10(1), 14-21.
Srinivas et al., "Enantiomeric Gas Chromatography Assay with Electron Capture Detection for d-Ritalinic Acid in Plasma", J. Chromatagraph, 1990, 530, 327-336.
Srinivas et al., "Sterioselective Disposition of Methylphenidate in Children with Attention Deficit Disorder", J. Pharmacol. Exp. Ther., 1987, 241(1), 300-306.
Staal et al., "Glutathione deficiency and human immunodeficiency virus infection", Lancet, 1992, 339, 909-912.
Uetrecht et al., "Idiosyncratic Drug Reactions: Possible Role of Reactive Metabolites Generated by Leukocytes", Pharmacol Res., 1989, 6(4), 265-273.
White et al., "methylphenidate as a Treatment for Depression in Acquired Immunodeficiency Syndrome: An n-of-1 Trial", J. Clin. Psychiatry, 1992, 53(5), 153-156.

Affiliated with

Also associated with

Rating

Chronic, bolus administration of D-threo methylphenidate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chronic, bolus administration of D-threo methylphenidate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chronic, bolus administration of D-threo methylphenidate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2275999