Chromosome I8Q loss and prognosis in colorectal cancer

Details Chromosome I8Q loss and prognosis in colorectal cancer Chromosome I8Q loss and prognosis in colorectal cancer

1994-10-05

1997-12-30

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

057028869

ABSTRACT:
To examine the status of chromosome 18q, polymorphic genetic markers and DNA from formalin-fixed, paraffin-embedded tumors are employed. DNA from normal tissue is used as a comparison. The status of chromosome 18q is prognostic of the survival among stage II and stage III colorectal cancer patients.

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Weissenbach et al., A second generation linkage map of the human genome, Nature 359: pp. 794-801, Oct. 29, 1992.
Jen et al., "Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer", New Engl. J. Med., 331(4):213-221 (1994).
Offerhaus et al., "The Relationship of DNA Aneuploidy to Molecular Genetic Alterations in Colorectal Carcinoma", Gastroenterology, 102:1612-1619 (1992).
Kern et al., "Allelic Loss in Colorectal Carcinoma", JAMA, 261(21):3099-3103 (1989).
O'Connell et al., "Current Status of Adjuvant Chemotherapy for Colorectal Cancer: Can Molecular Markers Play A Role in Predicting Prognosis?" Cancer, 70:Suppl. 1732-9(1992).
Laurent-Puig et al., "Survival and Acquired Genetic Alterations in Colorectal Cancer", Gastroenterology, 102:1136-1141 (1992).

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