Chromosome 9 and progressive rod-cone degeneration disease genet

Details Chromosome 9 and progressive rod-cone degeneration disease genet Chromosome 9 and progressive rod-cone degeneration disease genet

1997-07-10

1998-09-08

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435810, 536 2432, 536 2433, 935 77, 935 78, C12Q 170, C12P 1934, C07H 2104

Patent

active

058043888

ABSTRACT:
Provided are nucleic acid molecules which comprise at least a portion of a polymorphic genetic marker for determining whether a canine has a mutated progressive rod-cone degeneration disease (prcd) gene locus in one or both alleles. The genetic markers are located on canine chromosome 9 in a genomic region identified as the prcd-informative region. A method for making genetic markers representing polymorphic sequences located in the prcd-informative region of canine chromosome 9 comprises isolating a polymorphic DNA sequence in the prcd-informative region, using oligonucleotides complementary with at least a portion of the sequence to amplify the sequence, and analyzing canine chromosome 9 in a prcd-informative pedigree for the ability of the polymorphic sequence to co-segregate with the prcd gene locus by a linkage test. The presence of a mutated prcd gene locus in one or both alleles of a canine in a pedigree is detected by analyzing canine chromosome 9 in the canine for the presence of at least one polymorphic genetic marker, which co-segregates with the prcd gene locus, by a linkage analysis.

REFERENCES:
Ostrander et al. Genomics 16:207-213, Apr. 1993.
Ostander et al. Mammalian Genome 6:192-195, Mar. 1995.
Petra Werner et al., "Physical and Linkage Mapping of Human Chromosome 17 Loci to Dog Chromosomes 9 and 5", 1997, Genomics, vol. 42, pp. 74-82.

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