Chromosome 3p21.3 genes are tumor suppressors

Details Chromosome 3p21.3 genes are tumor suppressors Chromosome 3p21.3 genes are tumor suppressors

2011-03-08

2011-03-08

Schultz, James (Doug) (Department: 1633)

Nanotechnology

Specified use of nanostructure

For medical, immunological, body treatment, or diagnosis

C514S04400A, C435S006120

Reexamination Certificate

active

07902441

ABSTRACT:
Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.

REFERENCES:
patent: 2342470 (2002-09-01), None
patent: WO 98/16655 (1998-04-01), None
patent: WO 00/61626 (2000-10-01), None
patent: WO 02/076454 (2002-10-01), None
Richards (1997) Cell Mol. Life Sci. 53:790-802.
Wagener, Molecular Oncology: prospects for cancer diagnosis and therapy, published online at http://www.roche.com/pages/downloads/company/pdf/rtpenzberg01e.pdf.
Janmaat et al. (Clin. Cancer Res. Jun. 2003; 9:2316-2326.
Hsieh et al. Exp. Cell Res. 1999; 249: 109-115.
Shafer et al. Int. J. Oncol. Aug. 2003; 23 (2): 389-400.
Ji et al. (2005) Future Oncol. 1:79-92.
Dermer (1994) Bio/Technol. 12:320.
Gromeier et al. (2001) Cum. Opin. Mol. Ther. 3:503-308.
Gura (1997) Science 278: 1041-1042.
Bernues et al., “Analysis of 3p allelic losses in renal cell carcinomas: Comparison with cytogenetic results,”Cancer Genet Cytogenet; 107:121-124, 1998.
Buchhagen et al., “Two regions of homozygosity on chromosome 3p in squamous cell carcinoma of the head and neck: comparison with cytogenetic analysis,”Head&Neck, 18:529-537, 1996.
Burbee et al., “Epigenetic inactivationof RASSF1A in lung and breast cancers and malignant phenotype suppression,”J. Natl Cancer Inst., 93:691-699, 2001.
Daigo et al., “Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.31,”Canc. Research, 59:1966-1972, 1999.
Daly et al., “A homozygous deletion on chromosome 3 in small cell lung cancer cell line correlates with a region of tumor suppressive activity”,Oncogene8:1721-1729, 1993.
Dammann et al., “Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3,”Nat Genet, 25:315-319, 2000.
Duh et al., “A novel gene (Blu) that resides in the lung cancer region on chromosome 3p21.3 has the MYND Zn finger-like module—Human Blu protein (Blu) mRNA, completed cds,” Abstract, Database EMBL Sequence Library, Database Accession No. U70824, XP002207890, 1998.
Duh et al., “A novel gene (Blu) that resides in the lung cancer region on chromosome 3p21.3 has the MYND Zn finger-like module—Human Blu protein testis isoform (Blu) mRNA, complete cds,” Abstract, Database EMBL Sequence Library, Database Accession No. U70880, XP002207891, 1998.
Forgacs et al., “Mutation analysis of the PTEN/MMAC1 gene in lung cancer,”Oncogene, 17:1557-1565, 1998.
Gazdar et al., “Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer,”Internatl J Cancer, 78:766-774, 1998.
Gazdar et al., Molecular genetic changes found in human lung cancer and its precursor lesions.Cold Spring Harbor Sym Quant Biol, 59:565-572, 1994.
Gorunova et al., “Cytogenetic analysis of pancreatic carcinomas: Intratumor heterogeneity and nonrandom pattern of chromosome aberrations,”Genes Chrom Cancer, 23:81-99, 1998.
Hibi et al., “Three distinct regions involved in 3p deletion in human lung cancer,”Oncogene, 7:445-449, 1992.
Hughson et al., “Clear-cell and papillary carcinoma of the kidney: An analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification, cytogenetics, and fluorescence in situ hybridization,”Cancer Genet Cytogenet, 106:93-104, 1998.
Hung et al., “Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma,”JAMA, 273:558-563, 1995, Correction:JAMA, 273:1908, 1995.
Kersemaekers et al, “Allelic loss and prognosis in carcinoma of the uterine cervix,”Internatl J Cancer, 79:411-417, 1998.
Killary and Fournier, “Microcell fusion,”Methods in Enzymology, 254:133-152, 1995.
Killary et al., “Definition of a tumor suppressor locus within a human chromosome 3p21-p22,”Proc. Natl. Acad. Sci., 89:10877-10881, 1992.
Kohno et al., “p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma,”Cancer, 85:341-347, 1999.
Kok et al.,“A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes”,Cancer Res., 54:4183-4187, 1994.
Kok et al., “Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer,”Nature, 330:578-581, 1987.
Kok et al., “Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes,”Adv Cancer Res, 71:27-92, 1997.
Kondo et al., “Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozyogous deletion region leads to G1 arrest and growth inhibition of lung cancer cells,”Oncogene, 20:6258-6262, 2001.
Lerman and Minna, “The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes,”Cancer Res, 60:6116-6133, 2000.
Lin et al., “Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo,”Cancer Research, 62:2715-2720, 2002.
Minna et al., “Cancer of the Lung: Section 1: Molecular Biology of Lung Cancer,” In: DeVita Jr., et al., (editors.)Cancer: Principles and Practice of Oncology. 5 ed. Philadelphia: Lippincott-Raven Publishers, 849-857, 1997.
Mizuguchi and Kay, “Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method,”Hum.Gene Therap., 9:2577-2583, 1998.
Naylor et al, “Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer,”Nature, 329:451-454, 1987.
Neubauer et al., “Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma,”J. Natl. Cancer Inst., 89:1350-1355, 1997.
Pakula and Sauer, “Genetic analysis of protein stability and function,”Annu. Rev. Genet., 23:289-310, 1989.
Petersen et al., “Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 13q, and 17p,”Brit. J. Cancer75:79-86, 1997.
Roche et al., “Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin,”Oncogene, 12:1289-1297, 1996.
Sanchez et al., “A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo,”Proc Natl Acad Sci,U.S.A, 91:3383-3387, 1994.
Satoh et al., “Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer,”Mol Carcinogenesis, 7:157-164, 1993.
Sekido et al., “Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene,”Oncogene16:3151-3157, 1998.
Sekido et al, “Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns,”Proc Natl Acad Sci, U.S.A, 93:4120-4125, 1996.
Sekido et al., “Progress in understanding the molecular pathogenesis of human lung cancer,”Biochimica Biophysica Acta, 1378:F21-F59, 1998.
Shay, “Telomerase in cancer: diagnostic, prognostic, and therapeu

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