Chromosome 18Q loss and prognosis in colorectal cancer

Details Chromosome 18Q loss and prognosis in colorectal cancer Chromosome 18Q loss and prognosis in colorectal cancer

1996-01-29

1998-11-10

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 2433, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104

Patent

active

058341900

ABSTRACT:
To examine the status of chromosome 18q, polymorphic genetic markers and DNA from formalin-fixed, paraffin-embedded tumors are employed. DNA from normal tissue is used as a comparison. The status of chromosome 18q is prognostic of the survival among stage II and stage III colorectal cancer patients.

REFERENCES:
patent: 5075217 (1991-12-01), Weber
patent: 5283171 (1994-02-01), Manos et al.
patent: 5380645 (1995-01-01), Vogelstein
Jen et al., "Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer", New Engl. J. Med., 331(4):213-221 (1994).
Offerhaus et al., "The Relationship of DNA Aneuploidy to Molecular Genetic Alterations in Colorectal Carcinoma", Gastroenterology, 102:1612-1619 (1992).
Kern et al., "Allelic Loss in Colorectal Carcinoma", JAMA, 261(21):3099-3103 (1989).
O'Connell et al., "Current Status of Adjuvant Chemotherapy for Colorectal Cancer: Can Molecular Markers Play A Role in Predicting Prognosis?" Cancer 70:Suppl. 1732-9 (1992).
Laurent-Puig et al., "Survival and Acquired Genetic Alterations in Colorectal Cancer", Gastroenterology, 102:1136-1141 (1992).
Wassenbach et al., A Second Generation Linkage Map of the Human Gene, Nature 359; pp. 794-801, Oct. 29, 1992.
WO9109964--Vogelstein, B., Gene Deleted in Colorectal Cancer of Humans, pp. 1-31, 11, Jul. 1991.

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