Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-03-27
1999-08-17
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Vector, per se
435243, 435325, 536 231, 536 235, C12N 1500
Patent
active
059393165
ABSTRACT:
The present invention relates to the mammalian fsh22 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh22 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh22 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh22 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh22 and to using such compounds as therapeutic agents in the treatment of fsh22 disorders and neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of fsh22 disorders and neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment these disorders.
REFERENCES:
patent: 4109496 (1978-08-01), Allemann et al.
patent: 4215051 (1980-07-01), Schroeder et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5075217 (1991-12-01), Weber
patent: 5093246 (1992-03-01), Cech et al.
patent: 5364759 (1994-11-01), Caskey et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5585089 (1996-12-01), Queen et al.
M. Baron, Genetic linkage and bipolar affective disorder: progress and pitfalls, Mol. Psych. 2:200-210, 1997.
H. Ewald et al., Susceptibility loci for bipolar affective disorder on chromosone 18?, Psych. Gen. 7:1-12, 1997.
D.F. MacKinnon et al., Genetics of Manic Depressive Illness, Annu. Rev. Neurosci. 20:355-73, 1997.
B. Lewin, Genes IV, p. 805, 1990.
Altschul, S. et al., 1990, "Basic Local Alignment Search Tool", J. Mol. Biol. 215:403-410.
Ausubel, F.M. et al., eds., 1989, Current Protocols in Molecular Biology, vol. I, Green Publishing Associates, Inc., and John Wiley & Sons, Inc., NY, at p. 2.10.3.
Babiychuk, E. et al., 1995, "Arabidopsis thaliana NADPH Oxidoreductase Homologs Confer Tolerance of Yeasts toward the Thiol-oxidizing Drug Diamide" J. of Biological Chemistry 270:26224-26231.
Baron, M. et al., 1993, "Diminished Support for Linkage Between Manic Depressive Illness and X-Chromosome Markers in Three Israeli Pedigrees", Nature Genetics 3:49-55.
Baron, M. et al., 1987, "Genetic Linkage Between X-Chromosome Markers and Bipolar Affective Illness", Nature 326:289-292.
Been and Cech, 1986, "One Binding Site Determines Sequence Specificity of Tetrahymena Pre-rRNA Self-Splicing, Trans-Splicing, and RNA Enzyme Activity", Cell 47:207-216.
Benoist and Chambon, 1981, "In Vivo Sequence Requirements of the SV40 Early Promoter Region", Nature 290:304-310.
Berrettini, W. et al., 1994, "Chromosome 18 DNA Markers and Manic-Depressive Illness: Evidence for a Susceptibility Gene", Proc. Natl. Acad. Sci. USA 91:5918-5921.
Bertelsen, A. et al., 1977, "A Danish Twin Study of Manic-Depressive Disorders", Brit. J. Psychiat. 130:330-351.
Bird, R. et al., 1988, "Single-Chain Antigen-Binding Proteins", Science 242:423-426.
Bitter, G. et al., 1987, "Expression and Secretion Vectors for Yeast", Methods in Enzymology 153:516-544.
Brinster, R. et al., 1982, "Regulation of Metallothionein-Thymidine Kinase Fusion Plasmids Injected into Mouse Eggs", Nature 296:39-42.
Butler, J.E., 1981, "The Amplified ELISA: Principles of and Applications for the Comparitive Quantitation of Class and Subclass Antibodies and the Distribution of Antibodies and Antigens in Biochemical Separates", Methods in Enzymology 73:482-523.
Campbell, K.H.S. et al., 1996, "Sheep Cloned by Nuclear Transfer from a Cultured Cell Line", Nature 380:64-66.
Chien, C. et al., 1991, "The Two-Hybrid System: A Method to Identify and Clone Genes for Proteins that Interact with a Protein of Interest", Proc. Natl. Acad. Sci. USA 88:9578-9582.
Cohen, D. et al., 1993, "Premiere Generation de la Carte Physique du Genome Humain", C.R. Acad. Sci. 316:1484-1488.
Colbere-Garapin, F. et al., 1981, "A New Dominant Hybrid Selective Market for Higher Eukaryotic Cells", J. Mol. Biol. 150:1-14.
Cole, S.P.C. et al., 1985, "The EBV-Hybridoma Technique and its Application to Human Lung Cancer", Monoclonal Antibodies and Cancer Therapy, pp. 77-96.
Cote, R. et al., 1983, "Generation of Human Monoclonal Antibodies Reactive with Cellular Antigens", Proc. Natl. Acad. Sci. USA 80:2026-2030.
Creighton, T., 1983, "Proteins: Structures and Molecular Principles", W.H. Freeman & Co., NY, pp. 34-49.
Dunn, K.J. et al., 1996, "Rapid Neurite Formation in a Human Cortical Neuronal Cell Line", Int. J. Devl. Neuroscience 14:61-68.
Egeland, J. et al., 1987, "Bipolar Affective Disorders Linked to DNA Markers on Chromosome 11", Nature 325:783-787.
Freimer, N. et al., 1996, "Genetic Mapping Using Haplotype, Association and Linkage Methods Suggests a Locus for Severe Bipolar Disorder (BPI) at 18q22-q23", Nature Genetics 12:436-441.
Freimer and Reus, 1992, in The Molecular and Genetic Basis of Neurological Disease, Rosenberg et al., eds., Butterworths, NY, pp. 951-965.
Freimer, N.B. et al., 1996, "An Approach to Investigating Linkage for Bipolar Disorder Using Large Costa Rican Pedigrees", Neuropsychiatric Genetics 67:254-263.
Gautier, C. et al., 1987, ".alpha.-DNA IV: .alpha.-Anomeric and .beta.-Anomeric Tetrathymidylates Covalently Linked to Intercalating Oxazolopyridocarbazole. Synthesis, Physicochemical Properties and Poly (rA) Binding", Nucleic Acids Research 15:6625-6641.
Gordon, J., 1989, "Transgenic Animals", Intl. Rev. Cytol. 115:171-229.
Gu, H. et al., 1994, "Deletion of a DNA Polymerase .beta. Gene Segment in T Cells Using Cell Type-Specific Gene Targeting", Science 265:103-106.
Haseloff and Gerlach, 1988, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities", Nature 334:585-591.
Helene, C. et al., 1992, "Control of Gene Expression by Triple Helix-Forming Oligonucleotides", Ann. NY Acad. Sci. 660:27-36.
Helene, C. 1991, "The Anti-Gene Strategy: Control of Gene Expression by Triplex-Forming-Oligonucleotides", Anti-Cancer Drug Design 6:569-584.
Houghten, R. et al., 1991, "Generation and Use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Descovery", Nature 354:84-86.
Huse, W. et al., 1989, "Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda", Science 246:1275-1281.
Huston, J. et al., 1988, "Protein Engineering of Antibody Binding Sites: Recovery of Specific Activity in an Anti-Digoxin Single-Chain Fv Analogue Produced in Escherichia coli", Proc. Natl. Acad. Sci. USA 85:5879-5883.
Inoue, H. et al., 1987, "Sequence-Dependent Hydrolysis of RNA Using Modified Oligonucleotide Splints and RNase H", FEBS Letters 215:327-330.
Inoue, H. et al., 1987, "Synthesis and Hybridization Studies on Two Complementary Nona(2'-O-Methyl)Ribonucleotides", Nucleic Acids Research 15:6131-6148.
Inouye and Inouye, 1985, "Up-Promoter Mutations in the Ipp gene of Escherichia coli", Nucleic Acids Res. 13:3101-3109.
Janknecht, R. et al., 1991, "Rapid and Efficient Purification of Native Histidine-Tagged Protein Expressed by Recombinant Vaccinia Virus", Proc. Natl. Acad. Sci. USA 88:8972-8976.
Kelsoe, J. et al., 1989, "Re-Evaluation of the Linkage Relationship Between Chromosome 11p Loci and the Gene for Bipolar Affective Disorder in the Old Order Amish" Nature 342:238-243.
Kozbor and Roder, 1983, "The Production of Monoclonal Antibodies from Human Lymphocytes", Immunology Today 4:72-79.
Kohler and Milstein, 1975, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature 256:495-497.
Lakso, M. et al., 1992, "Targeted Oncogene Activation by Site-Specific Recombination in Transgenic Mice", Proc. Natl. Acad. Sci. USA 89:6232-6236.
Lam, K. et al., 1991, "A New Type of Synthetic Peptide Library for
Chen Hong
Freimer Nelson B.
Hutzell Paula K.
Millennium Pharmaceuticals Inc.
Pellegrino Susan
The Regents University of California
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