Chromosome 13-linked breast cancer susceptibility gene

Details Chromosome 13-linked breast cancer susceptibility gene Chromosome 13-linked breast cancer susceptibility gene

1998-03-20

2000-03-07

Hauda, Karen M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 72, 435 691, 435325, 4353201, 536 231, 536 235, C07H 2100, C12N 1563, C12N 1579, C12N 1511, C12N 1509

Patent

active

060338571

ABSTRACT:
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

REFERENCES:
"Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12," ANK Jacob et al., Oncogene (1996) 13, pp. 213-221.
"Generation of an Integrated Transcription Map of the BRCA2 Region on Chromosome 13q12-q13," Fergus J. Couch et al., Genomics 36, Article No. 0428 (1996), pp. 86-99.
"A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1," Yoshiio Miki et al., Science, vol. 266, Oct. 7, 1994, pp. 66-71.
"Different Tumor types from BRCA2 Carriers Show Wild-Type Chromosome Deletions on 13q12-q13.sup.1," Julius Gudmundsson et al., Cancer Research 55, Nov. 1, 1995, pp. 4830-4832.
"Somatic and Germline Mutations of the BRCA2 Gene in Sporadic Ovarian Cancer.sup.1," Karen A. Foster et al., Cancer Research 56, Aug. 15, 1996, pp. 3622-3625.
"A Common Mutation in BRCA2 That Predisposes to a Variety of Cancers Is Found in Both Jewish Ashkenazi and Non-Jewish Individuals.sup.1," David B. Berman et al., Cancer Research 56, Aug. 1, 1996, pp. 3409-3414.
"Patterns of Loss of Heterozygosity at Loci From Chromosome Arm 13q Suggest a Possible Involvement of BRCA2 in Sproadic Breast Tumors," Fabienne Kerangueven et al., Gene, Chromosomes on Cancer 13, (1995), p. 291-294.
"Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13," A-M Cleton-Jansen, et al., British Journal of Cancer (1995) 72, pp. 1241-1244.
"Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13," Nadine Collins et al., Short Report, Revised Jan. 30, 1995, accepted Jan. 30, 1995, pp. 1673-1675.
"Loss of Heterozygosity on Chomosome 13 is Common Only in the Biologically More Aggressive Subtypes of Ovarian Epithelial Tumors and Is Associated with Normal Retinoblastoma Gene Expression.sup.1," Timothy M. Kim et al., Advances in Brief, Accepted Dec. 17, 1993, pp. 605-609.
"BRCA2 germline mutations in male breast cancer cases and breast cancer families," Fergus J. Couch et al., Nature Genetics, vol. 13, May 1996, pp. 123-125.
"Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families," Catherine M. Phelan et al., Nature Genetics, vol. 13, May 1996, pp. 120-122.
"Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish woman affected by breast cancer," Susan Neuhausen et al., Nature Genetics, vol. 13, May 1996, pp. 126-128.
"Loss of heterozygosity in human ductal breast tumors indicated a recessive mutation on chromosome 13," Catharina Lundberg et al., Proc. Natl. Acad. Sci. USA, vol. 84, Apr. 1987, pp. 2372-2376.
"Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region," Mieke Schuttle et al., Proc. Natl. Acad. Sci. USA, vol. 92, Jun. 1995, pp. 5950-5954.
"Linkage to BRCA2 region in hereditary male breast cancer," Steinunn Thorlacius et al., The Lancet, vol. 346, No. 8974, Aug. 26, 1995, pp. 544-545.
"Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13," Richard Wooster et al., Science, vol. 265, Sep. 30, 1994, pp. 2088-2090.
"Identification of the breast cancer susceptibility gene BRCA2," Richard Wooster et al., Nature, vol. 378, Dec. 21/28, 1995, pp. 789-792.
"Regulating gene expression in transgenic animals," Catherine A. Kappel et al., Biotechnology 1992, 3, pp. 548-553.
"The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds," S. V. Tavtigian et al., Nature Genetics, vol. 12, Mar. 1996, pp. 333-337.
"Confirmation of a susceptibility locus on chromosome 13 in Australian breast cancer families," Sean M. Grimmond et al., Hum Genet (1996) 98, pp. 80-85.
"Further enigmatic variations," Kevin Davies, Nature, vol. 378, Dec. 21/28, 1995, pp. 762-763.

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