Chromosomal loci for the stringent control of gene...

Details Chromosomal loci for the stringent control of gene... Chromosomal loci for the stringent control of gene...

2003-08-06

2010-02-23

Hill, Kevin K. (Department: 1633)

Chemistry: molecular biology and microbiology

Vector, per se

C435S091400, C536S023100

Reexamination Certificate

active

07666668

ABSTRACT:
The invention relates to a method for obtaining a chromosomal locus for transgenesis of a multicellular eukaryotic organism, “MEO”, to a vector for transgenesis by homologous recombination of a MEO and to the use of such an vector for trans-genesis by homologous recombination of a MEO and to the transgenic MEO thus obtainable.

REFERENCES:
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Entrez Nucleotide Database entry for Accession No. AC122286, updated Nov. 25, 2003, downloaded Jun. 18, 2008.
Osoegawa et al. (2000) Genome Res. 10:116-128.
SEQ ID Search Results (Zhao et al, 2000; Konno et al, 2000; The Joint Genome Institute, 2000; Zhao et al, 2000).
Cameron, Mol. Biotech. 7(3):253-265, 1997.
Marth et al, Nature Genetics 23:452-456, 1999.
Wheelan et al, Genome Res. 11:1952-1957, 2001.
Baron, U. et al.: “Co-regulation of two gene activities by tetracycline via a bidirectional promoter,” Nucleic Acids Research, Oxford University Press, Surrey, GB, vol. 23, No. 17, Sep. 11, 1995, pp. 3605-3606.
St-Onge, L. et al.: “Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter,” Nucl. Acids Res., vol. 24, No. 19, 1996, pp. 3875-3877.
Database EBI DNA Sequences ′Online!, Jun. 2, 2002, “Mus musculus BAC clone RP23-111G16 from chromosome 6,” retrieved from EBI Database accession No. AC122874.

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