Chromophore blue adsorbent method for the purification of prepar

Details Chromophore blue adsorbent method for the purification of prepar Chromophore blue adsorbent method for the purification of prepar

1977-05-19

1979-10-23

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, A61K 4502

Patent

active

041720717

ABSTRACT:
The invention relates to a process for the purification of preparations having an interferon type-activity which comprises contacting the crude preparations with an adsorbent comprising as ligand a chromophore blue, equilibrated with an aqueous buffer whose concentration in salts is isomolar or hypomolar as compared with that of blood, and separating the fixed products having an interferon activity by using an aqueous buffer whose concentration in salts is hypermolar as compared with that of blood.
The purified preparations thus obtained are used as active ingredients of drugs having antiviral activity.

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patent: 3773924 (1973-11-01), Ho et al.
patent: 3975344 (1976-08-01), Schwartz
patent: 3981991 (1976-09-01), Stewart et al.
patent: 4016149 (1977-04-01), Travis et al.
patent: 4041152 (1977-08-01), Chany et al.
Proc. Soc. Exptl. Biol. & Med., vol. 153, No. 3, Dec., 1976, Cesario et al.
Chem. Abstract, vol. 77, 1972, 84911y, Boehme et al.

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