Chromone derivatives useful as antitumor agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549401, A61K 3135, C07D31130

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active

049046900

ABSTRACT:
A novel chromone derivative having a strong antitumor activity of the general formula: ##STR1## wherein R.sup.1 is an unsaturated alkyl or cycloalkyl group having 3 to 7 carbon atoms; R.sup.2 is hydrogen atom or a halogen atom; R.sup.3 is hydrogen atom or a lower alkyl group; and X is carboxyl group, or its salt, ester or amide.

REFERENCES:
patent: 4602034 (1986-07-01), Briet et al.
Atassi et al., Chemical Abstracts, vol. 104 (1986), No. 15, p. 19, Abstract No. 12257b.
Zaharka et al., Chemical Abstracts, vol. 106 (1987), No. 3, p. 37, Abstract No. 12501j.
Atassi et al., Eur. J. Med. Chem.--Chim. Ther. 1985--20, No. 5, pp. 393-402.
O'Dwyer et al., Cancer Chemother. Pharmacol. (1987) 19, pp. 6-10.

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