Chromone derivative, and aldose reductase inhibitor comprising s

Details Chromone derivative, and aldose reductase inhibitor comprising s Chromone derivative, and aldose reductase inhibitor comprising s

1994-10-12

1995-10-03

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549400, 549401, A61K 31355

Patent

active

054552672

ABSTRACT:
The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.

REFERENCES:
patent: 4532254 (1985-07-01), Okuda et al.
Komiya, et al., Studies on "Inchinko," I. Capillarisin, a New Choleretic Substance Journal of the Pharmaceutical Society of Japan, Jul. 1976, vol. 96, No. 7, pp. 841-862.
Chemical Abstracts, vol. III, 1989, p. 60, column 1. US Abstract No. 90199j, "Aldose Reductase Inhibitors of Inchinko".
Peter F. Kador, Norman E. Sharpless, Biophysical Chemistry, vol. 8, No. 1, Mar. 1978, pp. 81-85, "Structure-Activity Studies of Aldose Reductase Inhibitors Containing the 4-Oxo-4H Chromen Ring System".
A. Laurens et al. Therapeutique, vol. 38, No. 6, 1983, pp. 659-663 "Les Inhibiteurs de L'Aldose Reductase".
Tanimoto, Tsuyoshi (1988) Pharmacia 24:459.
Komiya, et al. Studies on "Inchinko," II Studies on the Compounds related to Capillarisin and Flavonoids. (1976) J. of Pharm. Soc. of Japan, 96:855.
Sato, et al. Inhibition of Aldehyde Reductase By Aldose Reductase Inhibitors (1990) Biochemical Pharmacology 40:1033-1042.
Sarges, et al., Spiro Hydantoin Aldose Reductase Inhibitors (1988) J. Med. Chem 31:230-243.
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Journal of the Pharmaceutical Society of Japan, Jul. 1976, vol. 96, No. 7, pp. 841-862.
Tanimoto, Tsuyoshi (1988) Pharmacia 24:459.
Sato et al (1990) Biochemical Pharmacology, 40:1033-1042.
Komiya et al (1976) J. of Pharm. Soc. of Japan 96:855.
Komiya et al (1976) J. of Pharm. Soc. of Japan 96:841.
Komiya, et al., Yakugaku Zasshi (1976) 96:7 855-862.

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