Chromone compounds, pharmaceutical compositions containing the s

Details Chromone compounds, pharmaceutical compositions containing the s Chromone compounds, pharmaceutical compositions containing the s

1996-08-09

1997-12-16

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 514406, 514414, 514422, 548256, 5482664, 5483051, 5483611, 5483644, 548464, 548525, C07D40704

Patent

active

056985754

ABSTRACT:
A chromone derivative of the formula (I): ##STR1## wherein R.sup.11 is a pyrazolyl, pyrrolyl, triazolyl, benzotriazolyl, benzimidazolyl, indazolyl, or indolyl group, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 is independently a hydrogen or halogen atom, or a hydroxy or alkoxy group, or an alkoxy group substituted with one or more alkoxy groups, and X is an oxygen or sulfur atom, or a salt thereof is disclosed. The chromone derivative inhibits the activity of matrix metalloproteinase.

REFERENCES:
Bantick et al, Journal of Heterocyclic Chemistry, 18(4):679-683 (1981).
Mazzei et al, Chemical Abstracts, 106(3):582, Abstract No. 18313w (1987).
Mazzei et al, Chemical Abstracts, 105(9):634, Abstract No. 78797w (1986).
Ellis et al., Benzopyrones, J.C.S. Perkin I, 2557-2560, 1981.
Reddy et al., Chemical Abstracts, vol. 83:114280k, 1975.

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