Chromogranin peptides

Details Chromogranin peptides Chromogranin peptides

1993-06-09

1996-05-07

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530324, C07K 500, C07K 700, C07K 1700

Patent

active

055147755

ABSTRACT:
This invention relates to the preparation and use of shortened synthetic chromogranin peptides capable of inhibiting parathyroid hormone secretion. The shortened synthetic chromogranin peptides of the invention are administered to treat hyperparathyroidism and to reverse bone resorption.

REFERENCES:
"The Chromogranin A and B: The First 25 Years and Future Perspectives", by Winkler et al., in Neuroscience, vol. 49, No. 3, pp. 497-528 (1992).
"Chromogranin A: Its Role In Endocrine Function and as an Endocrine and Neuroendocrine Tumor Marker", by Deftos, in Endocrine Reviews, vol. 12, No. 2, pp. 181-187 (1991).
"Bovine Parathyroid Glands Secrete a 26-kDa N-Terminal Fragment of Chromogranin-A which Inhibits Parathyroid Cell Secretion", by Drees et al., in Endocrinology, vol. 129, No. 6, pp. 3381-3387 (1991).
"A Chromogranin A-Derived Peptide Differentially Regulates the Secretion of Calcitonin Gene Products", by Deftos et al., in Journal of Bone and Mineral Research, vol. 5, No. 9, pp. 989-991 (1990).
"Autocrine Regulation of Parathyroid Secretion: Inhibition of Secretion by Chromogranin-A (Secretory Protein-I) and Potentiation of Secretion by Chromogranin-A and Pancreastatin Antibodies", by Fasciotto et al., in Endocrinology, vol. 127, No. 3, pp. 1329-1335 (1990).
"PTHrP Secretion is Stimulated by CT and Inhibited by CgA Peptides" by Deftos et al., in Endocrinology, vol. 125, No. l, pp. 563-565 (1989).
"Pancreastatin, a Presumed Product of Chromogranin-A (Secretory Protein-I) Processing, Inhibits Secretion from Porcine Parathyroid Cells in Culture", by Fasciotto et al., in Endocrinology, vol. 125, No. 3, pp. 1617-1622 (1989).
"The Sequence of Porcine Chromogranin A Messenger RNA Demonstrates Chromogranin A Can Serve as the Precursor for the Biologically Active Hormone Pancreastatin", by Iacangelo et al., in Endocrinology, vol. 122, No. 5, pp. 2339-2341 (1988).
"The Primary Structure of Human Secretonin I (Chromogranin B): Comparison with Chromogranin A Reveals Homologous Terminal Domains and a Large Intervening Variable Region", by Benedum et al., in The EMBO Journal, vol. 6, No. 5, pp. 1203-1211 (1987).
"Pancreastatin, a Novel Pancreatic Peptide that Inhibits Insulin Secretion", by Tatemoto et al., in Nature, vol. 324, pp. 476-478 (Dec. 4, 1986).
"The Molecular Function of Adrenal Chromaffin Granules: Established Facts and Unresolved Topics", by Winkler et al., in Neuroscience, vol. 18, No. 2, pp. 261-290 (1986).
"Secretogranins I and II: Two Tyrosine-Sulfated Secretory Proteins Common to a Variety of Cells Secreting Peptides by the Regulated Pathway", by Rosa et al., in Journal of Cell Biology, vol. 101, pp. 1999-2011 (Nov., 1985).

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