Chromogenic substrates

Details Chromogenic substrates Chromogenic substrates

1979-06-14

1980-09-09

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 23, 435 13, 435 24, C07C10352, C12Q 156, C12Q 138, C12Q 136

Patent

active

042217067

ABSTRACT:
The present invention comprises compounds of the formula ##STR1## and the biologically acceptable acid addition salts thereof, wherein R.sub.1 represents hydrogen or lower alkyl having 1 to 4 carbon atoms; R.sub.2 represents an alkylene having 2 to 4 carbon atoms; R.sub.3 represents amino or guanidino; R.sub.4 represents nitrophenyl, methylnitrophenyl, dinitropheyl, naphthyl, or nitronaphtyl; m is 2 or 3; and n is 3 or 4. The compounds of the present invention are analytical reagents useful for measuring proteolytic enzymes such as thrombin and trypsin. The enzymatic hydrolysis of the invention compounds provides a chromogenic amine by which the proteolytic enzyme concentration can be determined spectrophotometrically.

REFERENCES:
patent: 3748044 (1973-07-01), Liston
patent: 3884896 (1975-05-01), Blomback et al.
patent: 4070245 (1978-01-01), Svendsen

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