Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-08-17
1979-09-04
Rotman, Alan L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
560 34, C07C15309
Patent
active
041668251
ABSTRACT:
The present invention encompasses acid addition salts of a compound of the formula ##STR1## wherein: R.sub.1 represents phenylsulfonyl, benzoyl, carbobenzoxy, and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, phenyl, or hydroxy substituted derivatives thereof; or alkanoyl having 2-12 carbon atoms; R.sub.2 represents alkyl having 1-10 carbon atoms, alkoxyalkyl having 2-6 carbon atoms, cycloalkyl having 5-7 carbon atoms, benzyl and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, carboxy, hydroxy, or substituted derivatives thereof; R.sub.3 represents hydrogen or guanyl, and m is 3 or 4.
Compounds of the present invention are useful as analytical reagents. Enzymatic hydrolysis provides --S--R.sub.2 which can be further reacted with 5,5'-dithiobis (2-nitrobenzoic acid) to provide a colored product by which the enzyme concentration can be determined spectrophotometrically.
REFERENCES:
patent: 3884896 (1975-05-01), Blomback et al.
patent: 3886136 (1975-05-01), Claeson et al.
patent: 3966701 (1976-06-01), Dorman et al.
Klausner, et al., Interaction of .alpha.-N-(p-Toluenesulphonyl)-p-guanidino-L-phenylalanine. . ., Biochem. J., (1978), 169, pp. 157-167.
Farmer, et al., Use of N-benzoyl-L-tyrosine Thiobenzyl Ester as a Protease Substrate, Journal of Biological Chemistry, vol. 250, No. 18, pp. 7366-7371, (1975).
Magic Susan E.
Plattner Jacob J.
Voss Houston F.
Abbott Laboratories
McDonnell John J.
Niblack Robert L.
Rotman Alan L.
Whittenbaugh Robert C.
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