Chromogenic substances and use thereof for the determination...

Details Chromogenic substances and use thereof for the determination... Chromogenic substances and use thereof for the determination...

2008-07-29

2008-07-29

Powers, Fiona T (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

C534S770000, C534S787000, C534S794000, C534S798000, C534S885000, C435S024000

Reexamination Certificate

active

10751601

ABSTRACT:
The invention relates to chromogenic compounds and the use thereof for the determination of enzymes of the family of carboxypeptidases N and carboxypeptidases U. The above is more specifically a compound of formula (I) in which A=(1), (2), (3), (4) or (5), R1, R2=H, —CH3, —CH(CH3)2, —OCH3, —Cl,—CF3,—OCF3,—SCH3, R3=an amino acid group which may be hydrolysed by a carboxypeptidase A and R4=a basic amino acid group.

REFERENCES:
patent: 4551272 (1985-11-01), Sugiyama et al.
patent: 6461832 (2002-10-01), Gilvarg
Mock and Xu, “Catalytic activity of carboxypeptidase B and of Carboxypeptidase Y with anisylazoformyl substrates,” Bioorganic & Medicinal Chemistry Letters, vol. 9, pp. 187-192. (1999)/.
Mock et al., “Arazoformyl peptide surrogates as spectrophotometric kinetic assay substrates for carboxypeptidase A,” Analytical Biochemistry, vol. 239, pp. 218-222 (1996).
Mock and Stanford, “Arazoformyl dipeptide substrates for thermolysin. Confirmation of a reverse protonation catalytic mechanism,” Biochemistry vol. 35 No. 23 pp. 7369-7377 (1996).
Schatteman et al., “Assay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma,” Clinical Chemistry vol. 45, No. 6 pp. 807-813 (1999).

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