Chromogenic merocyanine enzyme substrates

Details Chromogenic merocyanine enzyme substrates Chromogenic merocyanine enzyme substrates

1992-02-26

1993-03-02

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 173, 536 177, 536 175, 435 18, 435 14, 435 19, 435 21, C07H 1704, C07H 506, C12Q 154, G01N 3358

Patent

active

051910730

ABSTRACT:
Chromogenic merocyanine enzyme substrate compounds of the general formula: ##STR1## where Y is an enzymatically-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid; A and B represent residues that complete 5- or 6-membered ring systems; R.sup.1 is substituted or unsubstituted alkyl; R.sup.2 and R.sup.3, independently, are hydrogen or lower alkyl; m, n, and p, which can be different, are integers from 0 through 3 provided that m+n+p must be at least 2; and X is an appropriate counterion (anion).

REFERENCES:
patent: 4536572 (1985-08-01), Kim et al.
patent: 4668622 (1987-05-01), Kuhr et al.
patent: 4754025 (1988-06-01), Makise et al.
patent: 4760135 (1988-07-01), Diedrich et al.
patent: 4760136 (1988-07-01), Mori et al.
Richardson et al.; "Chromogenic Substituted Arylethene Derivatives as Substrates for Hydrolytic Enzyme Assays"; Chemical Abstracts; (112) (11): 94609m.

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