Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme sub

Details Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme sub Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme sub

1991-11-29

1993-02-02

Griffin, Ronald W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 14, 435 22, 435 792, 435 23, 536 181, C12Q 154, C12Q 138, C12Q 100, C12Q 150

Patent

active

051837439

ABSTRACT:
Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e] [1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.

REFERENCES:
patent: Re31006 (1982-08-01), Schuurs et al.
patent: 4321364 (1982-03-01), McCleary
patent: 4517287 (1985-05-01), Scheibe et al.
patent: 4716222 (1987-12-01), Wallenfels et al.
patent: 4810636 (1989-03-01), Corey
patent: 4932871 (1990-06-01), Bell et al.
Graan et al, "Analytical Biochemistry" (144); 193-198; (1985).

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