Chromogenic compounds, processes for the preparation thereof and

Details Chromogenic compounds, processes for the preparation thereof and Chromogenic compounds, processes for the preparation thereof and

1988-03-31

1992-04-28

Doll, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

530329, 530330, 530331, 546294, 564194, 564200, 564437, C12Q 137, C07K 500, C07K 706, C07D21362

Patent

active

051088908

ABSTRACT:
The present invention provides compounds of the general formula: ##STR1## wherein R.sup.1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R.sup.2 and R.sup.3, which are the same or different, are hydrogen atoms, a lower alkyl, lower alkoxy, carboxyl or lower alkoxycarbonyl radicals or carboxamido groups optionally substituted by lower alkyl or, if R.sup.2 and R.sup.3 are adjacent, can represent a --CH.dbd.CH--CH.dbd.CH-- radical, Z is a conjugated-through positively charged, bicyclic heterocyclic system and X is an anion of an organic or inorganic acid. The present invention also provides processes for the preparation of these compounds and diagnostic agents containing them for the determination of peptide bond-cleaving enzymes.

REFERENCES:
patent: 4457866 (1984-07-01), Karges et al.
Allen et al. J. Am. Chem. Soc. Nov. 8, 1944, 66(11):1805-1810.
Haber et al., J. Cardiovasc. Pharmacol. 1987, 10(Suppl. 7):S54-S58.
Chemical Abstracts, vol. 105, Nr. 2-Jul. 1986, No. 7925a "Azomethine, azo and methine dyes of 5-hydroxy-, 5-amino- and 5-thiolo-3-methyl-1-phenyl-pyrazole".

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