Chromogenic compounds and the use thereof as enzyme substrates

Details Chromogenic compounds and the use thereof as enzyme substrates Chromogenic compounds and the use thereof as enzyme substrates

1991-10-11

1993-03-02

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 13, 435 19, C12Q 137, C12Q 144, C12Q 156

Patent

active

051908620

ABSTRACT:
The present invention provides compounds of the general formula: ##STR1## wherein R.sup.1 is an amino acid residue or a residue of an oligopeptide in which the amino groups are optionally substituted by protective groups, R.sup.2 and R.sup.3, which are the same or different, are hydrogen atoms, a lower alkyl, lower alkoxy, carboxyl or lower alkoxycarbonyl radicals or carboxamido groups optionally substituted by lower alkyl or, if R.sup.2 and R.sup.3 are adjacent, can represent a --CH.dbd.CH--CH.dbd.CH-- radical, Z is conjugated-through positively charged, bicyclic heterocyclic system and X is an anion of an organic or inorganic acid. The present invention also provides processes for the preparation of these compounds and diagnostic agents containing them for the determination of peptide bond-cleaving enzymes.

REFERENCES:
patent: 4457866 (1984-07-01), Karges et al.
patent: 4950593 (1990-08-01), Matta et al.

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